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2.A.5.4.9
Probable Zn2+ transporter, Zip13 (SLC39A13). Mice deficient in Zn transporter Slc39a13/Zip13 show changes in bone, teeth and connective tissue reminiscent of the clinical spectrum of human Ehlers-Danlos syndrome (EDS) (Fukada et al., 2008).

Accession Number:Q8BZH0
Protein Name:Zinc transporter ZIP13
Length:361
Molecular Weight:38502.00
Species:mus musculus (Mouse) [10090]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q8BZH0
eggNOG: roNOG06476
RefSeq: NP_080997.1   
Entrez Gene ID: 68427   
Pfam: PF02535   
KEGG: mmu:68427   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (3)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPGCPCPGCG MAGQRLLFLT VLALELLERA GGSQPALRSL GAAAACRLDN KESESWGALL 
61:	SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTLLQSE AGAWRLRQLL SFALGGLLGN 
121:	VFLHLLPEAW AYTCNITPGG EGQSLQRQQQ LGLWVIAGFL TFLALEKMFL NSKEDPSQAP 
181:	SKDPTAAALN GGHCLAQPAA EPGLRAVVRN LKVSGYLNLL ANTIDNFTHG LAVAASFLVS 
241:	KKIGLLTTMA ILLHEIPHEV GDFAILLRAG FDRWTAAKLQ FSTALGGLLG ACFAICTQSP 
301:	KGVEETVVWI LPFTSGGFLY IALVNVLPDL LEEDDPWHSL QQVLLLCSGV LVMVLLSLFV 
361:	E