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2.A.5.5.3
Zinc-regulated transporter 3, Zrt3 (Vacuolar membrane zinc transporter)

Accession Number:P34240
Protein Name:Zinc-regulated transporter 3
Length:503
Molecular Weight:55403.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: P34240
eggNOG: COG0428
HEGENOM: HOG000142066
DIP: DIP-5610N
Entrez Gene ID: 853679   
Pfam: PF02535   
KEGG: sce:YKL175W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis

References (7)

[1] “Sequencing and analysis of a 20.5 kb DNA segment located on the left arm of yeast chromosome XI.”  Vandenbol M.et.al.   8091858
[2] “Complete DNA sequence of yeast chromosome XI.”  Dujon B.et.al.   8196765
[3] “Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene.”  Wiemann S.et.al.   8154185
[4] “Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae.”  MacDiarmid C.W.et.al.   10856230
[5] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.”  Gruhler A.et.al.   15665377
[6] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKIPRWLLF SLISSVLCIL GALCVPLLSV AFDSKRNSQS KLVNYGLSLS AGSMITTSLY 
61:	MLLPRIEKSN RFKVFPGLLL GICLSFFLNY LVHAFASESL VHCADSGDHA TGSHIHSKSH 
121:	SHSHSHSHAD SHSNFSNDHD LENAPSEHGY ATSSSSVSEN DPLITKDSDR PQMKKKMSLI 
181:	DLLTRRKSEG ECCDLNKCTP LLQSEQPEYI ACVPPVIKSS QSERNVPHGC EGSEDNGQSD 
241:	DKDHRGLVCV ENNIGYDLEN LSLYRKNFLS SRHHHSSESP ENYGSNQLSH SFSSPLGNDV 
301:	TENPAALADT QYHPENGSLY PHHHHLETPF SKLLSIGMQT CLVLALHKFP EGFIIFYTNR 
361:	SDSSKSLGFS IFLSLTIHNF VEGFAMTLPF YTVFESKWVA ILITAVLGGG SQPLGALIGY 
421:	FIFKGSTPRD HEPNMDFLLS VTAGFLLVIG LQMFQTGIGF SDGHHHHQGE GDEEMKQSHS 
481:	SGTTCLKWCC TGVLLILASA LFT