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2.A.5.5.4
Probable zinc transporter zip2

Accession Number:O94402
Protein Name:Probable zinc transporter zip2
Length:389
Molecular Weight:42876.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

eggNOG: COG0428 COG0428
Entrez Gene ID: 2539302    2539302   
Pfam: PF02535    PF02535   
KEGG: spo:SPCC126.09    spo:SPCC126.09   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005789 C:endoplasmic reticulum membrane
GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis
GO:0005783 C:endoplasmic reticulum
GO:0005789 C:endoplasmic reticulum membrane
GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis

References (8)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “Comparative functional genomics of the fission yeasts.”  Rhind N.et.al.   21511999
[3] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372
[4] “Loss of Zhf and the tightly regulated zinc-uptake system SpZrt1 in Schizosaccharomyces pombe reveals the delicacy of cellular zinc balance.”  Boch A.et.al.   18637840
[5] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[6] “Comparative functional genomics of the fission yeasts.”  Rhind N.et.al.   21511999
[7] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372
[8] “Loss of Zhf and the tightly regulated zinc-uptake system SpZrt1 in Schizosaccharomyces pombe reveals the delicacy of cellular zinc balance.”  Boch A.et.al.   18637840

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNNSKGWILS LSINAFCVFG ASGIYLDKLV NKWFGYEVLD LANSDNALVT GLATSSGILL 
61:	YSSWASVMQE SFHFLEKISM FDTFLVRVFQ FCAFFFGGIV FYIFNHFLHK WLHESSQTGF 
121:	LHDHFSVSDP SPSTAQNHRS PPASCKRLSS CESSGSPSSR VVGSLQGSYC PSGTHLHEGS 
181:	LLLEDSSARH SSDSVHEYLV KKPSNCDCEC HAHFSSFPTH SGTPDDIEHI HSVYTMGIQT 
241:	ALLICLHKVP EGFITFLAST VDTGFMVLVA MSIHNIVEGF TIAYPLYLAW KSRPKAFLTA 
301:	ATLSSCSLPL GSLIAFLVME AGGIGSSDFL NFLYGIIFAG TAGMMLILSL RVILPEALRH 
361:	DHSENKRHSF ICFTIGILFT LFLEIFDSH