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2.A.52.1.3
Ni2+ -specific transporter, Nic1p (Eitinger et al. 2000).

Accession Number:O74869
Protein Name:Nic1P aka SPCC1884.02 aka SPCC757.01
Length:405
Molecular Weight:45295.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ni2+

Cross database links:

eggNOG: fuNOG06978
HEGENOM: HBG322888
RefSeq: NP_587676.2   
Entrez Gene ID: 2539250   
Pfam: PF03824   
KEGG: spo:SPCC1884.02   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005887 C:integral to plasma membrane
GO:0046872 F:metal ion binding
GO:0015099 F:nickel ion transmembrane transporter activity
GO:0015675 P:nickel ion transport
GO:0034254 P:regulation of urea catabolic process
GO:0055085 P:transmembrane transport

References (2)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “Nic1p, a relative of bacterial transition metal permeases in Schizosaccharomyces pombe, provides nickel ion for urease biosynthesis.”  Eitinger T.et.al.   10748059

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEYVKPRKN EFLRKFENFY FEIPFLSKLP PKVSVPIFSL ISVNIVVWIV AAIVISLVNR 
61:	SLFLSVLLSW TLGLRHALDA DHITAIDNLT RRLLSTDKPM STVGTWFSIG HSTVVLITCI 
121:	VVAATSSKFA DRWNNFQTIG GIIGTSVSMG LLLLLAIGNT VLLVRLSYWL WMYRKSGVTK 
181:	DEGVTGFLAR KMQRLFRLVD SPWKIYVLGF VFGLGFDTST EVSLLGIATL QALKGTSIWA 
241:	ILLFPIVFLV GMCLVDTTDG ALMYYAYSYS SGETNPYFSR LYYSIILTFV SVIAAFTIGI 
301:	IQMLMLIISV HPMESTFWNG LNRLSDNYEI VGGCICGAFV LAGLFGISMH NYFKKKFTPP 
361:	VQVGNDREDE VLEKNKELEN VSKNSISVQI SESEKVSYDT VDSKV