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2.A.53.2.10
The anion exchanger, channel and Na+-transporter, SLC26a9 (Chang et al. 2009). Differential contributions and interactions of SLC26A9 with CFTR to Cl- conductance in polarized and non-polarized epithelial cells have been demonstrated (Ousingsawat et al., 2012). Slc26a9 (-/-) mice have reduced gastric acid secretion (Chen et al., 2012). Polymorphisms in the human orthologue lead to altered activity and levels (Chen et al., 2012).

Accession Number:Q8BU91
Protein Name:Solute carrier family 26 member 9
Length:790
Molecular Weight:86852.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, anions

Cross database links:

Genevestigator: Q8BU91
eggNOG: roNOG12359
HEGENOM: HBG446299
RefSeq: NP_796217.2   
Entrez Gene ID: 320718   
Pfam: PF01740    PF00916   
KEGG: mmu:320718   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0015301 F:anion:anion antiporter activity
GO:0015106 F:bicarbonate transmembrane transporter activity
GO:0008271 F:secondary active sulfate transmembrane tran...
GO:0015701 P:bicarbonate transport
GO:0006821 P:chloride transport
GO:0006885 P:regulation of pH
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport

References (3)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+.”  Xu J.et.al.   15800055
[3] “Physiology of electrogenic SLC26 paralogues.”  Romero M.F.et.al.   17120765

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNQPRPRYVV DRAAYSLSLF DDEFEKKDRA YPVGEKLRNT FRCSSAKFKA FVFGLLPVLS 
61:	WLPKYKIKDY IIPDLLGGLS GGCIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGI 
121:	HQMVPGTFAV ISILVGNICL QLAPESKFQI FNNVTNETYV DTAAMEAERL HVSATLACLT 
181:	AVIQMALGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT 
241:	FIDICKNLPH TNIASLIFAL VSGVFLVLVK ELNARYMHKI HFPIPTEMIV VVVATAISGS 
301:	CKMPKKYHMQ IVGEIRQGFP TPVAPMVSQW KGMVGTAFSL AIVGYVINLA MGRTLASKHG 
361:	YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA GGKSQVASLC VSLVVMITML 
421:	VLGSYLYPLP KAVLGALIAV NLKNSLKQLT DPYYLWRKSK LDCCVWVVSF LSSFFLSLPY 
481:	GVAVGVAFSI LVVIFQTQFR NGSTLAQVMD TDIYVNPKTY NRAQEIAGVK IVTYCSPLYL 
541:	ANSEIFRQKV IAKTGMDPQK VLLAKQKYLR KQEKRTAIPT QQRKSLFMKT KTVSLQELQQ 
601:	DFESAPSTDP NNNQAPAAEA HISYITFSPD ASTAAACELP ASTRSPQEAS DTLASVPPFV 
661:	TFHTLILDMS GVSFVDLMGI KALAKLSSTY EKIGVQIFLV NIHAQVYNDI SHGGVFEDGC 
721:	VQRSHVFPSI HDAVLFAQAN AREAPDRNFH GAPGDTEFSL YDSEEEGPSY WDLEQEMFGT 
781:	MFHTETLTAL