TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.53.2.14
solute carrier family 26, member 8

Accession Number:Q96RN1
Protein Name:Testis anion transporter 1
Length:970
Molecular Weight:109006.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q96RN1 Q96RN1
eggNOG: COG0659 COG0659
HEGENOM: HOG000154234 HOG000154234
Entrez Gene ID: 116369   
Pfam: PF01740    PF00916   
KEGG: hsa:116369    hsa:116369   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015301 F:anion:anion antiporter activity
GO:0005254 F:chloride channel activity
GO:0019531 F:oxalate transmembrane transporter activity
GO:0005515 F:protein binding
GO:0015116 F:sulfate transmembrane transporter activity
GO:0030154 P:cell differentiation
GO:0007126 P:meiosis
GO:0007275 P:multicellular organismal development
GO:0007283 P:spermatogenesis

References (14)

[1] “Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.”  Toure A.et.al.   11278976
[2] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.”  Lohi H.et.al.   11834742
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure.”  Makela S.et.al.   15579655
[7] “The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.”  Toure A.et.al.   17517695
[8] “Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.”  Toure A.et.al.   11278976
[9] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.”  Lohi H.et.al.   11834742
[10] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[13] “Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure.”  Makela S.et.al.   15579655
[14] “The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.”  Toure A.et.al.   17517695

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV 
61:	QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL 
121:	IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFVKN 
181:	EFSAPSYLMG YNKSLSVVAT TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI 
241:	MLSQLTFIFG IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 
301:	FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD FSLLPKIILQ 
361:	AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN VVSSFFRSCV FTGAIARTII 
421:	QDKSGGRQQF ASLVGAGVML LLMVKMGHFF YTLPNAVLAG IILSNVIPYL ETISNLPSLW 
481:	RQDQYDCALW MMTFSSSIFL GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS 
541:	INDYREIITI PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 
601:	LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM NTSQTASEDQ 
661:	VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV AESQGRRSLI PYSDASLLPS 
721:	VHTIILDFSM VHYVDSRGLV VLRQICNAFQ NANILILIAG CHSSIVRAFE RNDFFDAGIT 
781:	KTQLFLSVHD AVLFALSRKV IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ 
841:	KNVSPGFIKI QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 
901:	EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV ERRRHPMDSY 
961:	SPEGNSNEDV