TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.53.2.15
Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9).  May play a role in chronic inflammatory airway diseases (Sala-Rabanal et al. 2015Sala-Rabanal et al. 2015).

Accession Number:Q7LBE3
Protein Name:Solute carrier family 26 member 9
Length:791
Molecular Weight:86988.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate anions

Cross database links:

Genevestigator: Q7LBE3
eggNOG: COG0659
HEGENOM: HOG000006546
Entrez Gene ID: 115019   
Pfam: PF01740    PF00916   
KEGG: hsa:115019   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015301 F:anion:anion antiporter activity
GO:0015106 F:bicarbonate transmembrane transporter activity
GO:0008271 F:secondary active sulfate transmembrane transporter activity
GO:0006821 P:chloride transport
GO:0006811 P:ion transport
GO:0006885 P:regulation of pH
GO:0055085 P:transmembrane transport

References (4)

[1] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.”  Lohi H.et.al.   11834742
[2] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+.”  Xu J.et.al.   15800055

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNA FRCSSAKIKA VVFGLLPVLS 
61:	WLPKYKIKDY IIPDLLGGLS GGSIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGV 
121:	HQMVPGTFAV ISILVGNICL QLAPESKFQV FNNATNESYV DTAAMEAERL HVSATLACLT 
181:	AIIQMGLGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT 
241:	FIDICKNLPH TNIASLIFAL ISGAFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG 
301:	CKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVSYVINLA MGRTLANKHG 
361:	YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA GGKSQVASLC VSLVVMITML 
421:	VLGIYLYPLP KSVLGALIAV NLKNSLKQLT DPYYLWRKSK LDCCIWVVSF LSSFFLSLPY 
481:	GVAVGVAFSV LVVVFQTQFR NGYALAQVMD TDIYVNPKTY NRAQDIQGIK IITYCSPLYF 
541:	ANSEIFRQKV IAKTGMDPQK VLLAKQKYLK KQEKRRMRPT QQRRSLFMKT KTVSLQELQQ 
601:	DFENAPPTDP NNNQTPANGT SVSYITFSPD SSSPAQSEPP ASAEAPGEPS DMLASVPPFV 
661:	TFHTLILDMS GVSFVDLMGI KALAKLSSTY GKIGVKVFLV NIHAQVYNDI SHGGVFEDGS 
721:	LECKHVFPSI HDAVLFAQAN ARDVTPGHNF QGAPGDAELS LYDSEEDIRS YWDLEQEMFG 
781:	SMFHAETLTA L