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2.A.53.2.16
Sulfate anion transporter 1 (SAT-1 or SAT1) (Solute carrier family 26 member 1); anion exchanger.  Transports chloride, sulfate, bicarbonate and oxalate (Regeer et al. 2003; Lee et al. 2003).  The mouse and rat orthologues have the same specificities and functions. Loss in mice  is associated with hyperoxalurea and calcium oxalate kidney stones, and specific mutations when heterozygous in humans cause urolithiasis (Dawson et al. 2013).  When homozygous, they can cause severe nephrocalcinosis.

Accession Number:Q9H2B4
Protein Name:Sulfate anion transporter 1
Length:701
Molecular Weight:75016.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Sulfate, Cl-, bicarbonate, Oxalate

Cross database links:

Genevestigator: Q9H2B4
eggNOG: COG0659
HEGENOM: HOG000006546
Entrez Gene ID: 10861   
Pfam: PF01740    PF00916   
KEGG: hsa:10861   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015108 F:chloride transmembrane transporter activity
GO:0019531 F:oxalate transmembrane transporter activity
GO:0008271 F:secondary active sulfate transmembrane transporter activity
GO:0015116 F:sulfate transmembrane transporter activity

References (5)

[1] “Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.”  Lohi H.et.al.   11087667
[2] “Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1).”  Regeer R.R.et.al.   12713736
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDESPEPLQQ GRGPVPVRRQ RPAPRGLREM LKARLWCSCS CSVLCVRALV QDLLPATRWL 
61:	RQYRPREYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY SLYTSFFANL IYFLMGTSRH 
121:	VSVGIFSLLC LMVGQVVDRE LQLAGFDPSQ DGLQPGANSS TLNGSAAMLD CGRDCYAIRV 
181:	ATALTLMTGL YQVLMGVLRL GFVSAYLSQP LLDGFAMGAS VTILTSQLKH LLGVRIPRHQ 
241:	GPGMVVLTWL SLLRGAGQAN VCDVVTSTVC LAVLLAAKEL SDRYRHRLRV PLPTELLVIV 
301:	VATLVSHFGQ LHKRFGSSVA GDIPTGFMPP QVPEPRLMQR VALDAVALAL VAAAFSISLA 
361:	EMFARSHGYS VRANQELLAV GCCNVLPAFL HCFATSAALA KSLVKTATGC RTQLSSVVSA 
421:	TVVLLVLLAL APLFHDLQRS VLACVIVVSL RGALRKVWDL PRLWRMSPAD ALVWAGTAAT 
481:	CMLVSTEAGL LAGVILSLLS LAGRTQRPRT ALLARIGDTA FYEDATEFEG LVPEPGVRVF 
541:	RFGGPLYYAN KDFFLQSLYS LTGLDAGCMA ARRKEGGSET GVGEGGPAQG EDLGPVSTRA 
601:	ALVPAAAGFH TVVIDCAPLL FLDAAGVSTL QDLRRDYGAL GISLLLACCS PPVRDILSRG 
661:	GFLGEGPGDT AEEEQLFLSV HDAVQTARAR HRELEATDAH L