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2.A.53.2.4
Pendrin (Pendred) syndrome (hereditary deafness) anion transporter (Na+-independent). Anions transported: iodide (thyroid gland; apical membrane of follicular epithelium); bicarbonate (kidney; apical membrane of intercalated cells of the cortical collecting duct), chloride, formate, etc. Pendrin probably catalyzes uniport and anion/anion antiport (SLC26A4). It also regulates Na+ absorption by the epithelial Na+ channel (Wall and Pech, 2008). CFTR controls the rate of liquid secretion while pendrin mediates transcellular HCO3- secretion in airway serous cells (Garnett et al., 2011).   A structural model has been presented (Bassot et al. 2016).

Accession Number:Q9R155
Protein Name:PDS aka SLC26A4
Length:780
Molecular Weight:85687.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate I-, bicarbonate, Cl-, formate

Cross database links:

Genevestigator: Q9R155
eggNOG: roNOG11962
HEGENOM: HBG446299
RefSeq: NP_035997.1   
Entrez Gene ID: 23985   
Pfam: PF01740    PF00916   
KEGG: mmu:23985   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0008271 F:secondary active sulfate transmembrane tran...
GO:0006885 P:regulation of pH
GO:0032880 P:regulation of protein localization
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear.”  Everett L.A.et.al.   10449762

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL ARSCSCSRKR 
61:	AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL QGMAYALLAA VPVQFGLYSA 
121:	FFPILTYFVF GTSRHISVGP FPVVSLMVGS VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT 
181:	RDAARVLLAS TLTLLVGIIQ LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL 
241:	NVSTKNYNGI LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI 
301:	PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML AASFSIAVVA 
361:	YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC FVATTALSRT AVQESTGGKT 
421:	QVAGLISAVI VMVAIVALGR LLEPLQKSVL AAVVIANLKG MFMQVCDVPR LWKQNKTDAV 
481:	IWVFTCIMSI ILGLDLGLLA GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE 
541:	EPEGVKILRF SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT 
601:	KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL 
661:	DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL EKMEQCGFFD DNIRKDRFFL 
721:	TVHDAILHLQ NQVKSREGQD SLLETVARIR DCKDPLDLME AEMNAEELDV QDEAMRRLAS