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2.A.53.2.6
Basolateral kidney cortical collecting duct and parietal cell chloride/sulfate/oxalate permease or channel, SLC26A7 [substrate preference: NO3- >> Cl- = Br- = I- > SO42- = Glucarate-] (minimal OH- and HCO3- transport; regulated by cytoplasmic pH) (Hwan et al., 2005).  May function as a channel (Ohana et al., 2008).

Accession Number:Q8TE54
Protein Name:Anion exchange transporter
Length:656
Molecular Weight:72213.00
Species: [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Recycling endosome membrane1 / Multi-pass membrane protein2
Substrate Cl-, Sulfate, Oxalate, nitrate, Br-, I-, Hydroxide, bicarbonate

Cross database links:

HOG000049231
Genevestigator: Q8TE54 Q8TE54
eggNOG: prNOG14210 COG0659
RefSeq: NP_439897.1    NP_599028.1   
Entrez Gene ID: 115111   
Pfam: PF01740    PF00916   
OMIM: 608479  gene
KEGG: hsa:115111    hsa:115111   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0055038 C:recycling endosome membrane
GO:0015380 F:anion exchanger activity
GO:0015106 F:bicarbonate transmembrane transporter activity
GO:0005254 F:chloride channel activity
GO:0019531 F:oxalate transmembrane transporter activity
GO:0015116 F:sulfate transmembrane transporter activity
GO:0015701 P:bicarbonate transport
GO:0006821 P:chloride transport
GO:0019532 P:oxalate transport
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport
GO:0005768 C:endosome
GO:0015301 F:anion:anion antiporter activity

References (14)

[1] “Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney.”  Vincourt J.-B.et.al.   11829495
[2] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.”  Lohi H.et.al.   11834742
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells.”  Petrovic S.et.al.   12736153
[5] “SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney.”  Kujala M.et.al.   15956810
[6] “Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion.”  Xu J.et.al.   16524946
[7] “Expression of ion transport-associated proteins in human efferent and epididymal ducts.”  Kujala M.et.al.   17504921
[8] “Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney.”  Vincourt J.-B.et.al.   11829495
[9] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.”  Lohi H.et.al.   11834742
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells.”  Petrovic S.et.al.   12736153
[12] “SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney.”  Kujala M.et.al.   15956810
[13] “Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion.”  Xu J.et.al.   16524946
[14] “Expression of ion transport-associated proteins in human efferent and epididymal ducts.”  Kujala M.et.al.   17504921

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ 
61:	QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA TGTFALTSLI SANAVERIVP 
121:	QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS 
181:	AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV 
241:	LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP 
301:	PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI 
361:	PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM 
421:	LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAIVIG RFPRAMTVSI 
481:	KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI 
541:	SKCEQNTLLN SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR 
601:	SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL SDHSEV