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2.A.53.3.11
Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7).  This complex links bicarbonate and dicarboxylate transport in some way with fatty acid biosynthesis (Moraes and Reithmeier 2012).

Accession Number:P0AFR2
Protein Name:Putative sulfate transporter ychM
Length:559
Molecular Weight:59429.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate HCO3-

Cross database links:

Genevestigator: P0AFR2 P0AFR2
EchoBASE: EB2293 EB2293
EcoGene: EG12392 EG12392
eggNOG: COG0659 COG0659
HEGENOM: HBG564176 HBG564176
DIP: DIP-48160N DIP-48160N
Structure:
3NY7     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKIFSSHVM PFRALIDACW KEKYTAARFT RDLIAGITVG IIAIPLAMAL AIGSGVAPQY 
61:	GLYTAAVAGI VIALTGGSRF SVSGPTAAFV VILYPVSQQF GLAGLLVATL LSGIFLILMG 
121:	LARFGRLIEY IPVSVTLGFT SGIGITIGTM QIKDFLGLQM AHVPEHYLQK VGALFMALPT 
181:	INVGDAAIGI VTLGILVFWP RLGIRLPGHL PALLAGCAVM GIVNLLGGHV ATIGSQFHYV 
241:	LADGSQGNGI PQLLPQLVLP WDLPNSEFTL TWDSIRTLLP AAFSMAMLGA IESLLCAVVL 
301:	DGMTGTKHKA NSELVGQGLG NIIAPFFGGI TATAAIARSA ANVRAGATSP ISAVIHSILV 
361:	ILALLVLAPL LSWLPLSAMA ALLLMVAWNM SEAHKVVDLL RHAPKDDIIV MLLCMSLTVL 
421:	FDMVIAISVG IVLASLLFMR RIARMTRLAP VVVDVPDDVL VLRVIGPLFF AAAEGLFTDL 
481:	ESRLEGKRIV ILKWDAVPVL DAGGLDAFQR FVKRLPEGCE LRVCNVEFQP LRTMARAGIQ 
541:	PIPGRLAFFP NRRAAMADL