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2.A.53.3.13
Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs.  It has an N-terminal Sulfate-tra-GLY domain with a glycine motif of unknown function and a C-terminal STAS (sulfate transporter and antisigma factor antagonist) domain.  The membrane-inserted domain consists of two intertwined inverted repeats of seven transmembrane segments, each resembling the fold of the (unrelated?) transporter, UraA. The structure shows an inward-facing, ligand-free conformation with a potential substrate-binding site at the interface between two helix termini in the center of the membrane (Geertsma et al. 2015). This structure defines the common framework for the diverse functional behavior of the SLC26 family.

Accession Number:Q1J2S8
Protein Name:Sulphate transporter
Length:499
Molecular Weight:53538.00
Species:Deinococcus geothermalis (strain DSM 11300) [319795]
Number of TMSs:11
Substrate Fumarate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTVHSPRFDL RQYQREWFAN PRKDVLAGIV VALALIPEAI AFSIIAGVDP QVGLYASFII 
61:	ALITAFLGGR PGMISAATGA MALLMTGLVK DHGIQYLFAA TVLTGVLQVV FGWAKLARYL 
121:	KFVPRSVMVG FVNALAILIF MAQLPQFVGA NWQMYAMVAA GLAIIYLLPL VFKAMPSALV 
181:	AIVVLTVVAV VTGADVKTVG DMGTLPTALP HFQFPQVPLT FETLAIIFPV ALTLSLVGLL 
241:	ESLLTAQLID ERTDTTSDKN VESRGQGVAN IVTGFFGGMA GCAMIGQSMI NVTSGGRGRL 
301:	STFVAGAFLM VLILALQPLL VQIPMAALVA VMMVVAISTF DWGSLRTLTV FPKGETVVML 
361:	ATVAVTVFTH DLSLGVLIGV VLSALFFARK VSQLSQVTPV DEVDGTRTYR VRGQLFFVST 
421:	HDFLHQFDFT HPARRVVIDL SDAHFWDGSA VGALDKVMLK FMRQGTSVEL RGLNAASATL 
481:	VERLAVHDKP DALDRMGGH