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2.A.53.3.8
SulP homologue with fused C-terminal carbonic anhydrase domain, probable bicarbonate uptake transporter (Felce and Saier, 2005)

Accession Number:Q8F8H7
Protein Name:Sulp homolog aka Carbonic anhydrase (EC 4.2.1.1)
Length:750
Molecular Weight:84288.00
Species:Leptospira interrogans [173]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Sulfate, bicarbonate

Cross database links:

HEGENOM: HBG336232
RefSeq: NP_710760.1   
Entrez Gene ID: 1149922   
Pfam: PF00484    PF00916   
BioCyc: LINT189518:LA0579-MONOMER   
KEGG: lil:LA0579    lil:LA_0579    lil:LA_0579   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0004089 F:carbonate dehydratase activity
GO:0005215 F:transporter activity
GO:0008270 F:zinc ion binding
GO:0015976 P:carbon utilization
GO:0055085 P:transmembrane transport

References (3)

[1] “Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.”  Ren S.-X.et.al.   12712204
[2] “Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.”  Ren S.-X.et.al.   12712204
[3] “Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.”  Ren S.-X.et.al.   12712204

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MALKPKEHIM NILYSFPRVS WDNLRHDFSA GLVVFLISLP LCIGIGFASG APIVSGLISG 
61:	IVGGIVISLI SKSPLSVSGP AAGLTVIVFD SIKTLGNFND FLLALCLAGI FQIILGFLKA 
121:	GILSNFFPSA VVKGMLAAIG VVLILKQIPH AIGYDIDYEG DMGFFQKDRE NTFSEILTAF 
181:	YRFTPGAIIL FTVALVLILI WEKFKLHEKF IIHGSLVAIV TGVLLNEMFR IFELGIVVSG 
241:	EHLIQPIQLN GALDLFLDDY SPNFSQWKNQ TIYFIAIKLC LVMSLETLLN LDAIEKIDPQ 
301:	RRIVSKNREL VAQGTGNLCS AILGGLPITS VIIRSSANLH AGARTRFSSF LHGLLILVSV 
361:	ILIPVWIAKI PLASLAAVLL VVGYKLTDYK ILQTQYKKGM DQFLPFISTL VGIVFTDILV 
421:	GIGIGCLFSV FFIMRRNILN PYQFNKKEMA YGVEVKIDLS EDVSFLNKSS MLYKLDKVPD 
481:	NAHLIIDGSR SKYIDPDVLE IIEDFKIVAR SRNIKLEIID VTSSYEKIQN KPLDLVLQQD 
541:	YQKLFENNRI WVEEKLSKDP DYFKNLALGQ TPQYLLISCS DSRLSVNEMT GTSAGELFVH 
601:	RNIANLVIDT DMNLMSVLQY SVEVLKVKHI VVCGHYDCGG VKTAIDGKYH GLIDAWLRHI 
661:	KQVYRMNRKE LSGILDENEK HERLVELNVR EQVYNLCMTT IVQNAWSRGN DLQLHGWVYD 
721:	LKQGKILDLN IDIDKDFRDY DIFRYQFETH