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2.A.55.1.2
Low-affinity Me2+ (Mn2+, Cu2+) uptake transporter, Smf2p.  Essential for manganese uptake.

Accession Number:P38778
Protein Name:SMF2 aka Smf2p aka YHR050W
Length:549
Molecular Weight:59768.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Mn2+, Cu2+

Cross database links:

Genevestigator: P38778
eggNOG: fuNOG04678
HEGENOM: HBG312498
DIP: DIP-4171N
RefSeq: NP_011917.1   
Entrez Gene ID: 856447   
Pfam: PF01566   
KEGG: sce:YHR050W   

Gene Ontology

GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005774 C:vacuolar membrane
GO:0015082 F:di-, tri-valent inorganic cation transmembr...
GO:0046872 F:metal ion binding
GO:0006877 P:cellular cobalt ion homeostasis
GO:0030026 P:cellular manganese ion homeostasis
GO:0006824 P:cobalt ion transport
GO:0006828 P:manganese ion transport

References (4)

[1] “Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein.”  West A.H.et.al.   1447206
[2] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[3] “The family of SMF metal ion transporters in yeast cells.”  Cohen A.et.al.   10930410
[4] “Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters.”  Portnoy M.E.et.al.   11027260

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM IGTLRKYARF 
61:	IGPGLMVSVS YMDPGNYSTA VAAGSAHRYK LLFSVLVSNF MAAFWQYLCA RLGAVTGLDL 
121:	AQNCKKHLPF GLNITLYILA EMAIIATDLA EVVGTAISLN ILFHIPLALG VILTVVDVLI 
181:	VLLAYKPNGS MKGIRIFEAF VSLLVVLTVV CFTVELFYAK LGPAKEIFSG FLPSKAVFEG 
241:	DGLYLSLAIL GATVMPHSLY LGSGVVQPRL REYDIKNGHY LPDANDMDNN HDNYRPSYEA 
301:	ISETLHFTIT ELLISLFTVA LFVNCAILIV SGATLYGSTQ NAEEADLFSI YNLLCSTLSK 
361:	GAGTVFVLAL LFSGQSAGIV CTLSGQMVSE GFLNWTVSPA LRRSATRAVA ITPCLILVLV 
421:	AGRSGLSGAL NASQVVLSLL LPFVSAPLLY FTSSKKIMRV QLNRTKELSR TTDKKPVADR 
481:	TEDDETIELE EMGIGSSSQE RSLVSPAPEY KDMSNGMIVT VLAIIVWLII SGLNFYMLLG 
541:	FTTGKEVHL