TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.55.1.3
Intracellular (Golgi?) heavy metal transporter, Smf3p

Accession Number:Q12078
Protein Name:SMF3 aka Smf3p aka YLR034C
Length:473
Molecular Weight:51775.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Metal ions

Cross database links:

Genevestigator: Q12078
eggNOG: fuNOG07838
HEGENOM: HBG312498
DIP: DIP-4163N
RefSeq: NP_013134.1   
Entrez Gene ID: 850721   
Pfam: PF01566   
KEGG: sce:YLR034C   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0046872 F:metal ion binding
GO:0005515 F:protein binding
GO:0005215 F:transporter activity
GO:0006879 P:cellular iron ion homeostasis
GO:0006826 P:iron ion transport

References (5)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[2] “The family of SMF metal ion transporters in yeast cells.”  Cohen A.et.al.   10930410
[3] “Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters.”  Portnoy M.E.et.al.   11027260
[4] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[5] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRSYMQILQK FAKFIGPGIL VSVAYMDPGN YATSVSGGAQ YKYTLLFSIF ISNIFAVLLQ 
61:	CLCVKLGTIT GYDLAENCRH NLPKKLNYTL YLFAEVAIIA TDLAEVVGTA IALQILFKIP 
121:	LTWGVLLTVL DVLVILMFYT PNGQSLKKVR VFEFGVGILV IGTCICFVLE LFKVSIPDKA 
181:	ELFKGFLPSN IIFKEQQALY ISLGILGATV MPHSLYLGSS IVKPRLHDYD LKKYGKVNAR 
241:	PSLSAIKYTL NYAYAELIIS LFLIATFVNS AILIVAGATL SGQPEAEDAD LLSIYKLLVH 
301:	YISPAAGLIF ALAMLCSGQS AGIICTLAGQ IVSEGFLQWS LPPWATRLCT RLIAIVPCLF 
361:	VTLTMGEKGI SDILNFSQVV LSLILPIVSA PLIYFTANRK LMVVHDENGV VRAPADVNAI 
421:	ADETTPLNSK HSKIVDFTNS RLLTYTSVFV WALIGSLNCY LVISYLLGAD IHF