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2.A.55.1.4
Manganese transporter Pdt1

Accession Number:Q10177
Protein Name:Manganese transporter pdt1
Length:521
Molecular Weight:57641.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Mn2+

Cross database links:

eggNOG: COG1914
HEGENOM: HOG000152204
Entrez Gene ID: 2542283   
Pfam: PF01566   
KEGG: spo:SPAC27F1.08   

Gene Ontology

GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005384 F:manganese ion transmembrane transporter activity
GO:0046872 F:metal ion binding
GO:0030026 P:cellular manganese ion homeostasis

References (4)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: the importance of Mn2+ homeostasis.”  Maeda T.et.al.   14723709
[3] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSQSYYMND LDDLRSLESS TLNKKDTAIN ELNPEQNDTR RSTDLLLEDK YGIQTGFSKY 
61:	WKKCTYGIRE YCKFIGPGFL IAVAYIDPGN YSTDLDAGSR FQYKLLFIVF LSNLFAVYLQ 
121:	SLCIRLGSVT GMDLARNCRE HYNRYICWSF YVLAEIAIIA TDIAEVIGTA VALKILMHIP 
181:	LVAGVVITIL DVLLVLIAWR PEGSMLSVRI FETAVALLVL VVAISFAVVL GRVHIGGAGT 
241:	VFKGFLPSST VFSREGLYSS IGILGATVMP HSLFLGSGLV QTRLRDLDVR RGNYTPVGDC 
301:	SDYRPTHETI KHSLTYSIVE VALSLFTFAL FTNSSILIVA GAVFYNTSGA DTSDLFSIYD 
361:	LLKEYVSISC GRLFAVALLF SGMSAGYVCT IAGQIVSEGY INWNLRPWLR RVITRAIAII 
421:	PCLVVSAAVG QSGLNQVLNA SQVCLSILLP FLTFPLVMFT CSRKVMRVVS DSTNEETGQL 
481:	IRETHDYSLG WTMTIVTWAI WLFLTALNLL LIVWLGMGVS F