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2.A.55.2.18
NRAMP4 of 512 aas and 12 TMSs, a vacuolar metal transporter involved in intracellular metal homeostasis. It can transport iron (Fe), manganese (Mn) and cadmium (Cd), and regulates metal accumulation under Fe starvation. It acts redundantly with NRAMP3 (which is 85% identical to it) to mobilize vacuolar Fe and provide sufficient Fe during seed germination (Lanquar et al. 2005). In association with NRAMP3, it is required for optimal growth and photosynthesis under Mn deficiency. It exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts (Lanquar et al. 2010). Its ortholog in Thlaspi japonicum has been characterized (Mizuno et al. 2005).

Accession Number:Q9FN18
Protein Name:Metal transporter Nramp4
Length:512
Molecular Weight:56385.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MSETDRERPL LASEERAYEE TEKVLIVGID EEEDADYDDD PGNSPKFSWK KLWLFTGPGF 
61:	LMSIAFLDPG NLESDLQAGA IAGYSLIWLL MWATAIGLLI QLLSARLGVA TGRHLAELCR 
121:	EEYPTWARMV LWIMAEIALI GADIQEVIGS AIAIKILSNG LVPLWAGVVI TALDCFIFLF 
181:	LENYGIRKLE AVFAILIATM ALAFAWMFGQ TKPSGTELLV GALVPKLSSR TIKQAVGIVG 
241:	CIIMPHNVFL HSALVQSREV DPKKRFRVKE ALKYYSIEST GALAVSFIIN VFVTTVFAKS 
301:	FYGTEIADTI GLANAGQYLQ DKYGGGFFPI LYIWAIGVLA AGQSSTITGT YAGQFIMGGF 
361:	LNLKMKKWVR ALITRSCAII PTMIVALVFD SSDSMLDELN EWLNVLQSVQ IPFAVIPLLC 
421:	LVSNEQIMGS FKIQPLVQTI SWIVAALVIA INGYLMVDFF SGAATNLILL VPVIIFAIAY 
481:	VVFVLYLISR GLTYTPWQLV ASSHKEPQRD DE