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2.A.55.2.4
The major root plasma membrane high affinity Me2+(Fe2+ Co2+ Mn2+) uptake transporter, NRAMP-1 (stimulated by Mn2+ deficiency) (Cailliatte et al., 2010).  In silico analyses of plant NRAMPs have been performed  using NRAMP1 as the query sequence (Vatansever et al. 2016).

Accession Number:Q9SAH8
Protein Name:Metal transporter Nramp1
Length:532
Molecular Weight:57562.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fe2+, Co2+, Mn2+

Cross database links:

Genevestigator: Q9SAH8 Q9SAH8
HEGENOM: HBG312498 HBG312498
Entrez Gene ID: 844422   
Pfam: PF01566   
KEGG: ath:AT1G80830    ath:AT1G80830   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005381 F:iron ion transmembrane transporter activity
GO:0005384 F:manganese ion transmembrane transporter act...
GO:0034755 P:iron ion transmembrane transport
GO:0055071 P:manganese ion homeostasis

References (4)

[1] “Involvement of NRAMP1 from Arabidopsis thaliana in iron transport.”  Curie C.et.al.   10769179
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Involvement of NRAMP1 from Arabidopsis thaliana in iron transport.”  Curie C.et.al.   10769179
[4] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAATGSGRSQ FISSSGGNRS FSNSPLIENS DSNQIIVSEK KSWKNFFAYL GPGFLVSIAY 
61:	IDPGNFETDL QAGAHYKYEL LWIILVASCA ALVIQSLAAN LGVVTGKHLA EQCRAEYSKV 
121:	PNFMLWVVAE IAVVACDIPE VIGTAFALNM LFSIPVWIGV LLTGLSTLIL LALQKYGVRK 
181:	LEFLIAFLVF TIAICFFVEL HYSKPDPGEV LHGLFVPQLK GNGATGLAIS LLGAMVMPHN 
241:	LFLHSALVLS RKIPRSASGI KEACRFYLIE SGLALMVAFL INVSVISVSG AVCNAPNLSP 
301:	EDRANCEDLD LNKASFLLRN VVGKWSSKLF AIALLASGQS STITGTYAGQ YVMQGFLDLR 
361:	LEPWLRNLLT RCLAIIPSLI VALIGGSAGA GKLIIIASMI LSFELPFALV PLLKFTSCKT 
421:	KMGSHVNPMA ITALTWVIGG LIMGINIYYL VSSFIKLLIH SHMKLILVVF CGILGFAGIA 
481:	LYLAAIAYLV FRKNRVATSL LISRDSQNVE TLPRQDIVNM QLPCRVSTSD VD