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2.A.55.3.7
H+-stimulated, divalent metal cation uptake system, MntH of 436 aas and 11 TMSs. The x-ray structure has been determined, revealing the probable ion translocation pathway (Bozzi et al. 2016). Metal ion and proton may enter the transporter via the same external pathway to the ir binding sites, but they follow separate routes to the cytoplasm, which could facilitate the co-transport of two cationic species (Bozzi et al. 2019). The results illustrate the flexibility of the LeuT fold to support a broad range of substrate transport and conformational change mechanisms. Transmembrane helix 6b links proton- and metal-release pathways and drives conformational changes (Bozzi et al. 2019).

Accession Number:Q9RTP8
Protein Name:Divalent metal cation transporter MntH
Length:436
Molecular Weight:46652.00
Species:Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [243230]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+, Metal ions

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FASTA formatted sequence
1:	MDSRSPSLPD DRPDPPEQHL DARAGATLRG TAGPRGVRRI LPFLGPAVIA SIAYMDPGNF 
61:	ATNIEGGARY GYSLLWVILA ANLMAMVIQN LSANLGIASG RNLPELIRER WPRPLVWFYW 
121:	IQAELVAMAT DLAEFLGAAL AIQLLTGLPM FWGAVVTGVV TFWLLNLQKR GTRPLELAVG 
181:	AFVLMIGVAY LVQVVLARPD LAAVGAGFVP RLQGPGSAYL AVGIIGATVM PHVIYLHSAL 
241:	TQGRIQTDTT EEKRRLVRLN RVDVIAAMGL AGLINMSMLA VAAATFHGKN VENAGDLTTA 
301:	YQTLTPLLGP AASVLFAVAL LASGLSSSAV GTMAGDVIMQ GFMGFHIPLW LRRLITMLPA 
361:	FIVILLGMDP SSVLILSQVI LCFGVPFALV PLLLFTARRD VMGALVTRRS FTVIGWVIAV 
421:	IIIALNGYLL WELLGG