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2.A.57.1.4
Equilibrative low affinity nucleoside transporter (nitrobenzyl-thioinosine-insensitive) (transports adenosine, inosine and hypoxanthine with high affinity; other nucleosides are transported with lower affinity)

Accession Number:O54699
Protein Name:rENT2 aka SLC29A2 aka ENT2
Length:456
Molecular Weight:50265.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Adenosine, Inosine, Hypoxanthine, Nucleosides

Cross database links:

Genevestigator: O54699
eggNOG: roNOG11626
RefSeq: NP_113926.1   
Entrez Gene ID: 65194   
Pfam: PF01733   
KEGG: rno:65194   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005337 F:nucleoside transmembrane transporter activity
GO:0015853 P:adenine transport
GO:0032869 P:cellular response to insulin stimulus
GO:0015854 P:guanine transport
GO:0035344 P:hypoxanthine transport
GO:0007595 P:lactation
GO:0035364 P:thymine transport
GO:0015862 P:uridine transport

References (1)

[1] “Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues.”  Yao S.Y.M.et.al.   9353301

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAHGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA ETPSTNHTSP 
61:	TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG SLLAILLLFA LTAALVKVDL 
121:	SPGLFFSITM ASVWFINSFC AVLQGSLFGQ LGTMPSTYST LFLSGQGLAG IFAALAMLTS 
181:	LASGVDPQTS ALGYFITPCV GILLSIICYL SLPHLKFARY YLTKKPQAPV QELETKAELL 
241:	GADEKNGIPV SPQQAGPTLD LDPEKELELG LEEPQKPGKP SVFVVFRKIW LTALCLVLVF 
301:	TVTLSVFPAI TAMVTTSSNS PGKWSQFFNP ICCFLLFNVM DWLGRSLTSY FLWPDEDSQL 
361:	LPLLVCLRFL FVPLFMLCHV PQRARLPIIF WQDAYFITFM LLFAISNGYF VSLTMCLAPR 
421:	QVLPHEREVA GALMTFFLAL GLSCGASLSF LFKALL