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2.A.57.2.2
Nucleoside (nucleobase, drug) transporter of 463 aas, AT1 or P2.  Transports adenosine and adenine as well as the drugs, melarsoprol, pentamidine, diminazene and cordycepin (Schmidt et al. 2018).

Accession Number:Q9Y0H9
Protein Name:TbAT1 aka AT1R
Length:463
Molecular Weight:51028.00
Species:Trypanosoma brucei [5691]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Nucleosides

Cross database links:

Pfam: PF01733   

Gene Ontology

GO:0016020 C:membrane
GO:0005337 F:nucleoside transmembrane transporter activity
GO:0006810 P:transport

References (1)

[1] “A nucleoside transporter from Trypanosoma brucei involved in drug resistance.”  Maser P.et.al.   10398598

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLGFDSANEF IVYVTFLFFG MSVVVVTNSI FSMPFFFIEY YKYAQGKPDA KPEDPKFWKH 
61:	MFTYYSIAAF VVELVLASLM LTPIGRRISV TVRLGVGLVI PIVLVFSVMM VTIVTTTETG 
121:	AKVTIMLIAI ANGVAMTLCD AGNAALIAPF PTKFYSSVVW GIAVCGVVTS FFSIVIKTSM 
181:	EGGYHNMLIQ SRIYFGLVMF MQVISCALLV LLRKNPYAQK YAAEFRYAAR KGIDDKGAGG 
241:	DEGNGAAKGP ADQDDDPHGG DDTDKGNVMT ATVDPDTMKD MDQVESITTS QQMLMARVWN 
301:	VFWRVWPMLF ACFMVFFTTF LVYPAVYFAI KADTGDGWYL TIAAALFNLG DFLSRLCLQF 
361:	KALHVSPRWV LIGTFARMLP IIPLVLCVRS IITGPWLPYI LVHAWGFTYG YYGGISQIYA 
421:	PRTGSLTTAG ERSLAANWTI ISLLGGIFVG AMFALAVNEG LPK