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2.A.57.2.6
High affinity purine nucleobase (hypoxanthine, guanine, xanthine, adenine, allopurinol) transporter, NT3 (Ortiz et al., 2007)

Accession Number:Q4QG33
Protein Name:NT3
Length:501
Molecular Weight:54604.00
Species:Leishmania major [5664]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Hypoxanthine, Xanthine, guanine, Adenine, Allopurinol

Cross database links:

HEGENOM: HBG525438
RefSeq: XP_001681865.1   
Entrez Gene ID: 5650150   
Pfam: PF01733   
KEGG: lma:LmjF13.1210   

Gene Ontology

GO:0016020 C:membrane
GO:0005337 F:nucleoside transmembrane transporter activity
GO:0006810 P:transport

References (1)

[1] “The genome of the kinetoplastid parasite, Leishmania major.”  Ivens A.C.et.al.   16020728

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MILNFSSLAE LYVYTTCVLL GVSMLMPLNA LASAPAYMLD YYKYATRDPN AKPNSPIFWN 
61:	HILTFYNVAS VVTQALVGPT VLTPWARKLS LSFRFFMALT LMMVEVFVIL VIPAGGVSQV 
121:	GAMVAFFIVT IAAGVGKSYL EATCYALVGT MPPKFMSAIM FGCGFSGVLS STLQCIIKAS 
181:	MEDTYDSVLR QAYLYFSLAL GFMAVALAMA LSLRFNSYAQ EHVGEYRAIK RANEAAKGLN 
241:	AEETNKAARE EMNGALSSSS KRQPFSTNPV AQGSEIYGDL IDEEAEKARC KAEGAGGSDE 
301:	LSECDEVRAV GRQAGDTCSD SNSDDRNLTT SEQLQRTRAW PVAKFIWPLM ASCFCNFFVS 
361:	LLILPSLIIP VDRTDRWFAT IAILLYNCGD ATGRWLSSVK LLWPSHLVLF ISIGCRFIFI 
421:	PLTFLCIFKY IPGHAAPHVL FALLGLTNGF FGAISMVFGP IDTRLRTEGQ RVMAGQLMGV 
481:	SLLAGASLSA LLAMAIVPFL P