TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.57.5.1
Battenin (BTN) or ceroid lipofuscinosis neuronal-3 (CLN3), with 6 TMSs and the N- and C-termini in the cytoplasm (Nugent et al. 2008).  May function in trafficking from the Golgi to the plasma membrane (Tecedor et al. 2013).  Mutations give rise to the disease, juvenile neuronal ceroid lipofuscinosis (JNCL) or Batten disease in humans, a fatal childhood-onset neurodegenerative disorder caused by mutations in CLN3.  May indirectly regulate activity of the Na+,K+-ATPase (Uusi-Rauva et al. 2008).

Accession Number:Q61124
Protein Name:Battenin
Length:438
Molecular Weight:47657.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Lysosome membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q61124 Q61124
eggNOG: NOG325947 NOG325947
HEGENOM: HOG000164765 HOG000164765
Entrez Gene ID: 12752    12752   
Pfam: PF02487    PF02487   
KEGG: mmu:12752    mmu:12752   

Gene Ontology

GO:0005776 C:autophagic vacuole
GO:0005901 C:caveola
GO:0044433 C:cytoplasmic vesicle part
GO:0005769 C:early endosome
GO:0000139 C:Golgi membrane
GO:0005795 C:Golgi stack
GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005770 C:late endosome
GO:0005765 C:lysosomal membrane
GO:0005624 C:membrane fraction
GO:0043005 C:neuron projection
GO:0005634 C:nucleus
GO:0008021 C:synaptic vesicle
GO:0005802 C:trans-Golgi network
GO:0042987 P:amyloid precursor protein catabolic process
GO:0015809 P:arginine transport
GO:0008306 P:associative learning
GO:0000046 P:autophagic vacuole fusion
GO:0006520 P:cellular amino acid metabolic process
GO:0051480 P:cytosolic calcium ion homeostasis
GO:0006681 P:galactosylceramide metabolic process
GO:0001575 P:globoside metabolic process
GO:0006678 P:glucosylceramide metabolic process
GO:0035235 P:ionotropic glutamate receptor signaling pathway
GO:0007042 P:lysosomal lumen acidification
GO:0035752 P:lysosomal lumen pH elevation
GO:0043086 P:negative regulation of catalytic activity
GO:0016242 P:negative regulation of macroautophagy
GO:0043524 P:negative regulation of neuron apoptotic process
GO:0045861 P:negative regulation of proteolysis
GO:0050885 P:neuromuscular process controlling balance
GO:0042133 P:neurotransmitter metabolic process
GO:0016485 P:protein processing
GO:0006898 P:receptor-mediated endocytosis
GO:0001508 P:regulation of action potential
GO:0010468 P:regulation of gene expression
GO:0006684 P:sphingomyelin metabolic process
GO:0007034 P:vacuolar transport
GO:0047496 P:vesicle transport along microtubule
GO:0005776 C:autophagic vacuole
GO:0005901 C:caveola
GO:0044433 C:cytoplasmic vesicle part
GO:0005769 C:early endosome
GO:0000139 C:Golgi membrane
GO:0005795 C:Golgi stack
GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005770 C:late endosome
GO:0005765 C:lysosomal membrane
GO:0005624 C:membrane fraction
GO:0043005 C:neuron projection
GO:0005634 C:nucleus
GO:0008021 C:synaptic vesicle
GO:0005802 C:trans-Golgi network
GO:0042987 P:amyloid precursor protein catabolic process
GO:0015809 P:arginine transport
GO:0008306 P:associative learning
GO:0000046 P:autophagic vacuole fusion
GO:0006520 P:cellular amino acid metabolic process
GO:0051480 P:cytosolic calcium ion homeostasis
GO:0006681 P:galactosylceramide metabolic process
GO:0001575 P:globoside metabolic process
GO:0006678 P:glucosylceramide metabolic process
GO:0035235 P:ionotropic glutamate receptor signaling pathway
GO:0007042 P:lysosomal lumen acidification
GO:0035752 P:lysosomal lumen pH elevation
GO:0043086 P:negative regulation of catalytic activity
GO:0016242 P:negative regulation of macroautophagy
GO:0043524 P:negative regulation of neuron apoptotic process
GO:0045861 P:negative regulation of proteolysis
GO:0050885 P:neuromuscular process controlling balance
GO:0042133 P:neurotransmitter metabolic process
GO:0016485 P:protein processing
GO:0006898 P:receptor-mediated endocytosis
GO:0001508 P:regulation of action potential
GO:0010468 P:regulation of gene expression
GO:0006684 P:sphingomyelin metabolic process
GO:0007034 P:vacuolar transport
GO:0047496 P:vesicle transport along microtubule

References (8)

[1] “Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3.”  Lee R.L.et.al.   8812504
[2] “Cross-species homology of the CLN3 gene.”  Taschner P.E.M.et.al.   9151313
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319
[5] “Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3.”  Lee R.L.et.al.   8812504
[6] “Cross-species homology of the CLN3 gene.”  Taschner P.E.M.et.al.   9151313
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGSSAGSWRR LEDSEREETD SEPQAPRLDS RSVLWKNAVG FWILGLCNNF SYVVMLSAAH 
61:	DILKQEQASG NQSHVEPGPT PTPHNSSSRF DCNSISTAAV LLADILPTLV IKLLAPLGLH 
121:	LLPYSPRVLV SGVCSAGSFV LVAFSQSVGL SLCGVVLASI SSGLGEVTFL SLTAFYPSAV 
181:	ISWWSSGTGG AGLLGSLSYL GLTQAGLSPQ HTLLSMLGIP VLLLASYFLL LTSPEPLDPG 
241:	GENEAETAAR QPLIGTETPE SKPGASWDLS LQERWTVFKG LLWYIIPLVL VYFAEYFINQ 
301:	GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLQCC RIRFTWVLAL LQCLNLALLL 
361:	ADVCLNFLPS IYLIFIIILY EGLLGGAAYV NTFHNIALET SDKHREFAME AACISDTLGI 
421:	SLSGVLALPL HDFLCHLP