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2.A.57.5.2
Protein BTN1

Accession Number:P47040
Protein Name:Protein BTN1
Length:408
Molecular Weight:46383.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P47040
eggNOG: NOG325947
HEGENOM: HOG000164765
DIP: DIP-4761N
Entrez Gene ID: 853387   
Pfam: PF02487   
KEGG: sce:YJL059W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0031301 C:integral to organelle membrane
GO:0015809 P:arginine transport
GO:0051453 P:regulation of intracellular pH
GO:0007034 P:vacuolar transport
GO:0007033 P:vacuole organization

References (8)

[1] “The subcellular location of the yeast Saccharomyces homologue of the protein defective in the juvenile form of Batten disease.”  Croopnick J.B.et.al.   9753630
[2] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.”  Galibert F.et.al.   8641269
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase.”  Pearce D.A.et.al.   9219333
[5] “Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.”  Pearce D.A.et.al.   10319861
[6] “The yeast model for Batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.”  Chattopadhyay S.et.al.   11053386
[7] “A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease.”  Kim Y.et.al.   14660799
[8] “Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae.”  Kim Y.et.al.   15701790

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDKSHQIYC YFWLFGLINN VLYVVILSAA VDIVGPTLPK SLVLLADIFP SLAIKLCSPF 
61:	FIDRIKYSYR IWSLITMSCL GMFLVSFKNL FVCLLGISFA SISSGFGEVT FLQLTHYYKQ 
121:	ISLNGWSSGT GGAGIIGGAS YMFLTSIFKV PVKLTLLVFS LLPFAFLFYF KLESNDTNLT 
181:	YQSLQQIDEA EDDQLVPFPV AFTHTNASQS LYSTRQHILQ TVKRLRRLVF PYMVPLTTVY 
241:	LFEYLINQAV APTLLFPING DERSKSMPFF FHKYRDIYVT YGTLYQLGVF ISRSFGHLMR 
301:	MRSLYILAFL QGVNLCITVL QSWFYVTHSP WAVMILIFYE GFLGGASYVN TFLNILEQED 
361:	PDETEFAMGA VSIADSFGVF LAALLGLGLE PKLCRHQIAD DRPWCRME