TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.58.1.1









Renal Na+-dependent phosphate transport protein 2 (NPT2). Catalyzes 3Na+:1Pi symport (Ghezzi et al., 2009).

Eukaryota
Metazoa
NPT2 of Rattus norvegicus (Q60825)
*2.A.58.1.2









Na+-dependent phosphate transporter, NptA (Lebens et al. 2002).

Bacteria
Proteobacteria
NptA of Vibrio cholerae
*2.A.58.1.3









Renal Na+/phosphate electroneutral symporter, NPTIIc, NPT2a or NaPi-IIc; responsible for hypophosphatemic hypercalciuric nephrolithiasis associated with rickets (Stechman et al., 2007). Catalyzes 2Na+:1Pi symport (Ghezzi et al., 2009). Interacts functionally with CFTR (Bakouh et al., 2012). Also interacts with PDZ1 but not PDZ2 of NHERF1 (Mamonova et al. 2015).

Eukaryota
Metazoa
SLC34A3 of Homo sapiens
*2.A.58.1.4









Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na+-dependent phosphate cotransporter 2B) (NaPi-2B) (Sodium/phosphate cotransporter 2B) (Na+/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2).  The membrane potential and cation interactions induce large-scale structural rearrangements of the protein (Patti et al. 2016).

Eukaryota
Metazoa
SLC34A2 of Homo sapiens
*2.A.58.1.5









Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A; Na+-dependent phosphate cotransporter 2A; NaPiIIa; NaPi-3; NaPi-2a) (Solute carrier family 34 member 1; SLC34A1) of 639 aas and 12 TMSs.  Co-transports 3 Na+ with 1 divalent phosphate anion.  There are 3 Na+ binding sites, N1 (binds Na+ or Li+), N2 and N3, (both of which are Na+-specific); residues comprising N1 have been identified (Fenollar-Ferrer et al. 2015).

Eukaryota
Metazoa
SLC34A1 of Homo sapiens
*2.A.58.1.6









Sodium-dependent phosphate transporter, NaPi-IIA. The stoichiometry is probably 3 Na+ to 1 phosphate molecules.  Orthologous to 2.A.58.1.4.  Predicted to have 12 TMSs with both the N- and C-termini intracellular (Radanovic et al. 2006).  The Km for phosphate is 80 μM (Zhifeng et al. 2012). 

Eukaryota
Metazoa
NaPi-IIB of Sus scrofa
*2.A.58.1.7









Sodium:phosphate cotransporter of 621 aas and 10 TMSs, NaPi-IIb (SLC34a2).  The amino acid sequence showed 79.0 and 70.9% sequence identity to the Astyanax mexicanus and Pundamilia nyererei orthologues, respectively. The  protein had eight predicted TMSs, with the amino and carboxy termini intracellular (Chen et al. 2016). Three isoforms have been evaluated with respect to the effects of diatary inorganic phosphate and vitamin D in several tisseues have been determined (Chen et al. 2017).

Eukaryota
Metazoa
NaPi-IIb of Tachysurus fulvidraco (Yellow catfish) (Pimelodus fulvidraco)
*2.A.58.2.1









Inorganic phosphate transporter, YjbB.  May be able to catalyze both uptake and efflux (Motomura et al. 2011; Ebert et al. 2013).

Bacteria
Proteobacteria
YjbB of E. coli (P0AF43)
*2.A.58.2.2









8 TMS NaPi co-transporter with a PhoU C-terminal domain

Bacteria
Fusobacteria
NaPi transporter of Fusobacterium nucleatum
*2.A.58.2.3









NaPi cotransporter with 8 TMSs and a C-terminal PhoU domain

Bacteria
Firmicutes
NaPi transporter of Natranaeoblius thermophilus
*2.A.58.2.4









Na+/Pi cotransporter of 616 aas (Ebert et al. 2013).

Bacteria
Proteobacteria
Phosphate transporter of Dinoroseobacter shibae
*2.A.58.2.5









Uncharacterized protein of 370 aas and 9 TMSs

UP of Salinarchaeum sp. Harcht-Bsk1
*2.A.58.2.6









Putative Na+-dependent phosphate symporter of 558 aas and 9 TMSs.

Archaea
Euryarchaeota
PNaS family member of Methanocella arvoryzae