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2.A.58.1.1
Renal Na+-dependent phosphate transport protein 2 (NPT2). Catalyzes 3Na+:1Pi symport (Ghezzi et al., 2009).

Accession Number:Q06496
Protein Name:NPT2 aka SLC34A1 aka SLC17A2
Length:637
Molecular Weight:68707.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, phosphate

Cross database links:

Genevestigator: Q06496
eggNOG: roNOG12682
RefSeq: NP_037162.1   
Entrez Gene ID: 25548   
Pfam: PF02690   
KEGG: rno:25548   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0016021 C:integral to membrane
GO:0015321 F:sodium-dependent phosphate transmembrane tr...
GO:0015293 F:symporter activity
GO:0006817 P:phosphate transport
GO:0032026 P:response to magnesium ion
GO:0006814 P:sodium ion transport

References (8)

[1] “Expression cloning of human and rat renal cortex Na/Pi cotransport.”  Magagnin S.et.al.   8327470
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Regulation of rat renal Na/Pi-cotransporter by parathyroid hormone: immunohistochemistry.”  Lotscher M.et.al.   8691716
[4] “Acute regulation by dietary phosphate of the sodium-dependent phosphate transporter (NaP(i)-2) in rat kidney.”  Katai K.et.al.   9058191
[5] “Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.”  Pfister M.F.et.al.   9465116
[6] “Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters.”  Forster I.C.et.al.   10198426
[7] “Studies on the topology of the renal type II NaPi-cotransporter.”  Lambert G.et.al.   10370077
[8] “Cysteine residues and the structure of the rat renal proximal tubular type II sodium phosphate cotransporter (rat NaPi IIa).”  Lambert G.et.al.   10926678

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMSYSERLGG PAVSPLPVRG RHMVHGAAFA YVPSPQVLHR IPGTTTYAIS SLSPVALTEH 
61:	SCPYGEVLEC HDPLPAKLAQ EEEQKPEPRL SQKLAQVGTK LLKVPLMLGF LYLFVCSLDV 
121:	LSSAFQLAGG KVAGDIFKDN AILSNPVAGL VVGILVTVLV QSSSTSTSII VSMVSSGLLE 
181:	VSSAIPIIMG SNIGTSVTNT IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA 
241:	TGYLHHVTGL VVASFNIRGG RDAPDLLKVI TEPFTKLIIQ LDKSVITSIA VGDESLRNHS 
301:	LIRIWCQPET KEASTSMSRV EAIGSLANTT MEKCNHIFVD TGLPDLAVGL ILLAGSLVVL 
361:	CTCLILLVKM LNSLLKGQVA NVIQKVINTD FPAPFTWVTG YFAMVVGASM TFVVQSSSVF 
421:	TSAITPLIGL GVISIERAYP LTLGSNIGTT TTAILAALAS PREKLSSSFQ IALCHFFFNI 
481:	SGILLWYPLP CTRLPIRMAK ALGKRTAKYR WFAVLYLLVC FLLLPSLVFG ISMAGWQAMV 
541:	GVGTPFGALL AFVVLVNVLQ SRSPGHLPKW LQTWDFLPRW MHSLQPLDGL ITRATLCYAR 
601:	PEPRSPQLPP RVFLEELPPA TPSPRLALPA HHNATRL