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2.A.58.1.5
Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A; Na+-dependent phosphate cotransporter 2A; NaPiIIa; NaPi-3; NaPi-2a) (Solute carrier family 34 member 1; SLC34A1) of 639 aas and 12 TMSs.  Co-transports 3 Na+ with 1 divalent phosphate anion.  There are 3 Na+ binding sites, N1 (binds Na+ or Li+), N2 and N3, (both of which are Na+-specific); residues comprising N1 have been identified (Fenollar-Ferrer et al. 2015).

Accession Number:Q06495
Protein Name:Sodium-dependent phosphate transport protein 2A
Length:639
Molecular Weight:68937.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate phosphate, Na+

Cross database links:

Genevestigator: Q06495
eggNOG: COG1283
HEGENOM: HOG000070039
Entrez Gene ID: 6569   
Pfam: PF02690   
KEGG: hsa:6569   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0031526 C:brush border membrane
GO:0005887 C:integral to plasma membrane
GO:0015321 F:sodium-dependent phosphate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0046849 P:bone remodeling
GO:0055062 P:phosphate ion homeostasis
GO:0046686 P:response to cadmium ion
GO:0010288 P:response to lead ion
GO:0032026 P:response to magnesium ion
GO:0046689 P:response to mercury ion
GO:0006814 P:sodium ion transport

References (6)

[1] “Expression cloning of human and rat renal cortex Na/Pi cotransport.”  Magagnin S.et.al.   8327470
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[4] “A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism.”  Courbebaisse M.et.al.   22506049
[5] “Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.”  Prie D.et.al.   12324554
[6] “A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome.”  Magen D.et.al.   20335586

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSYGERLGS PAVSPLPVRG GHVMRGTAFA YVPSPQVLHR IPGTSAYAFP SLGPVALAEH 
61:	TCPCGEVLER HEPLPAKLAL EEEQKPESRL VPKLRQAGAM LLKVPLMLTF LYLFVCSLDM 
121:	LSSAFQLAGG KVAGDIFKDN AILSNPVAGL VVGILVTVLV QSSSTSTSII VSMVSSGLLE 
181:	VSSAIPIIMG SNIGTSVTNT IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA 
241:	TGYLHHITRL VVASFNIHGG RDAPDLLKII TEPFTKLIIQ LDESVITSIA TGDESLRNHS 
301:	LIQIWCHPDS LQAPTSMSRA EANSSQTLGN ATMEKCNHIF VDTGLPDLAV GLILLAGSLV 
361:	LLCTCLILLV KMLNSLLKGQ VAKVIQKVIN TDFPAPFTWV TGYFAMVVGA SMTFVVQSSS 
421:	VFTSAITPLI GLGVISIERA YPLTLGSNIG TTTTAILAAL ASPREKLSSA FQIALCHFFF 
481:	NISGILLWYP VPCTRLPIRM AKALGKRTAK YRWFAVLYLL VCFLLLPSLV FGISMAGWQV 
541:	MVGVGTPFGA LLAFVVLINV LQSRSPGHLP KWLQTWDFLP RWMHSLKPLD HLITRATLCC 
601:	ARPEPRSPPL PPRVFLEELP PATPSPRLAL PAHHNATRL