TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.59.1.1









Plasma membrane ACR3 arsenite exporter (AsIII:H+ antiporter) (Wysocki et al., 1997).  Catalyzes proton antiport with either arsenite or antimonite.  Cys151 is essential for transport activity, while Cys90 and Cys169 are important in trafficking (Maciaszczyk-Dziubinska et al. 2013).  Other residues important for folding, trafficking and/or activity have also been identified (Markowska et al. 2015). This protein has 10 TMSs with cytoplasmically oriented N- and C-termini, and a homology-based structural model of Acr3 using the crystal structure of the Yersinia frederiksenii homologue of the human bile acid sodium symporter, ASBT, has been constructed (Wawrzycka et al. 2016).

Eukaryota
Fungi
ACR3 of Saccharomyces cerevisiae
*2.A.59.1.2









ArsB arsenite/antimonite exporter (Sato and Kobayashi, 1998)
Bacteria
Firmicutes
ArsB of Bacillus subtilis (spP45946)
*2.A.59.1.3









The arsenical resistance membrane protein, the arsenate (not arsenite) transporter, So_ACR3 (Xia et al., 2008) (with 7 putative TMSs and an N-terminus in the periplasm).
Bacteria
Proteobacteria
ACR3 of Shewanella oneidensis (Q8EJD3)
*2.A.59.1.4









Arc3 homologue

Archaea
Euryarchaeota
Acr3 of Pyrococcus furiosus (Q8U3B8)
*2.A.59.1.5









The arsenite-specific exporter, Acr3/ArsA1/ArsA2. ArsA1 and ArsA2 are half sized ATPases (Fu et al., 2010).

Bacteria
Firmicutes
The Acr3/ArsA1/ArsA2 arsenite exporter of Alkaliphilus metalliredigens 
Acr3 (A6TP80)
ArsA1 (A6TP82)
ArsA2 (A6TP83) 
*2.A.59.1.6









The arsenite-specific exporter, Acr3'/ArsA1'/ArsA2'. ArsA1' and ArsA2' are half sized ATPases (Fu et al., 2009; 2010)

Bacteria
Firmicutes
The Acr3'/ArsA1'/ArsA2' arsenite exporter of Alkaliphilus metalliredigens 
Acr3' (A6TLY3)
ArsA1' (A6TLY5)
ArsA2' (A6TLY6) 
*2.A.59.1.7









Aresenite (AsIII):H+ antiporter, Acr3-1; confers resistance to As(III) but not Sb(III) (antimonite) (Villadangos et al. 2012; Yang et al. 2012).

Bacteria
Actinobacteria
Acr3-1 of Corynebacterium glutamicum
*2.A.59.2.1









Putative efflux pump (Acr3)

Bacteria
Proteobacteria
Acr3 of Sulfitobacter sp. NAS-14.1 (A3T1V5)  
*2.A.59.2.2









Acr3 homologue of unknown function (10 putative TMSs)

Bacteria
Chloroflexi
Acr3 of Chloroflexus aggregans (B8GAD2)