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2.A.6.1.1
Heavy metal (Ni2+ and Co2+) efflux pump, CnrA.  Functions with CnrB (TC# 8.A.1.2.1) and CnrC (TC# 1.B.17.2.1) (Grass et al. 2000; Tibazarwa et al. 2000).

Accession Number:P37972
Protein Name:Nickel and cobalt resistance protein cnrA
Length:1076
Molecular Weight:115738.00
Species:Ralstonia metallidurans [266264]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Ni2+, Co2+

Cross database links:

eggNOG: COG3696
HEGENOM: HBG301912
RefSeq: YP_161705.1    YP_161714.1    YP_582009.1    YP_582019.1   
Entrez Gene ID: 3187355    3187363    4036638    4036648   
Pfam: PF00873   
KEGG: rme:Rmet_6210   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0006812 P:cation transport

References (2)

[1] “Characterization of the inducible nickel and cobalt resistance determinant cnr from pMOL28 of Alcaligenes eutrophus CH34.”  Liesegang H.et.al.   8380802
[2] “Regulation of the cnr cobalt and nickel resistance determinant from Ralstonia sp. strain CH34.”  Grass G.et.al.   10671463

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIESILSGSV RYRWLVLFLT AVVAVIGAWQ LNLLPIDVTP DITNKQVQIN SVVPTMSPVE 
61:	VEKRVTYPIE TAIAGLNGVE STRSMSRNGF SQVTVIFKES ANLYFMRQQV SERLAQARPN 
121:	LPENVEPQMG PVSTGLGEVF HYSVEYQYPD GTGASIKDGE PGWQSDGSFL TERGERLDDR 
181:	VSRLAYLRTV QDWIIRPQLR TTPGVADVDS LGGYVKQFVV EPDTGKMAAY GVSYADLARA 
241:	LEDTNLSVGA NFIRRSGESY LVRADARIKS ADEISRAVIA QRQNVPITVG QVARVKIGGE 
301:	LRSGAASRNG NETVVGSALM LVGANSRTVA QAVGDKLEQI SKTLPPGVVI VPTLNRSQLV 
361:	IATIETVAKN LIEGALLVVA ILFALLGNWR AATIAALVIP LSLLVSAIGM NQFHISGNLM 
421:	SLGALDFGLI IDGAVIIVEN SLRRLAERQH REGRLLTLDE RLQEVVQSSR EMVRPTVYGQ 
481:	LVIFMVFLPC LTFQGVEGKM FSPMVITLML ALASAFVLSL TFVPAMVAVM LRKKVAETEV 
541:	RVIVATKESY RPWLEHAVAR PMPFIGAGIA TVAVATVAFT FVGREFMPTL DELNLNLSSV 
601:	RIPSTSIDQS VAIDLPLERA VLSLPEVQTV YSKAGTASLA ADPMPPNASD NYIILKPKSE 
661:	WPEGVTTKEQ VIERIREKTA PMVGNNYDVT QPIEMRFNEL IGGVRSDVAV KVYGENLDEL 
721:	AATAQRIAAV LKKTPGATDV RVPLTSGFPT FDIVFDRAAI ARYGLTVKEV ADTISTAMAG 
781:	RPAGQIFDGD RRFDIVIRLP GEQRENLDVL GALPVMLPLS EGQARASVPL RQLVQFRFTQ 
841:	GLNEVSRDNG KRRVYVEANV GGRDLGSFVD DAAARIAKEV KLPPGMYIEW GGQFQNLQAA 
901:	TKRLAIIVPL CFILIAATLY MAIGSAALTA TVLTAVPLAL AGGVFALLLR GIPFSISAAV 
961:	GFIAVSGVAV LNGLVLISAI RKRLDDGMAP DAAVIEGAME RVRPVLMTAL VASLGFVPMA 
1021:	IATGTGAEVQ KPLATVVIGG LVTATVLTLF VLPALCGIVL KRRTAGRPEA QAALEA