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2.A.6.1.3
Silver ion (Ag+)-specific efflux pump

Accession Number:Q9ZHC9
Protein Name:SilA
Length:1048
Molecular Weight:114604.00
Species:Salmonella typhimurium [90371]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Ag+

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0008324 F:cation transmembrane transporter activity
GO:0006812 P:cation transport

References (1)

[1] “Molecular basis for resistance to silver cations in Salmonella.”  Gupta A.et.al.   9930866

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIEWIIRRSV ANRFLVMMGA LFLSIWGTWT IINTPVDALP DLSDVQVIIK TSYPGQAPQI 
61:	VENQVTYPLT TTMLSVPGAK TVRGFSQFGD SYVYVIFEDG TDLYWARSRV LEYLNQVQGK 
121:	LPAGVSSEIG PDATGVGWIF EYALVDRSGK HDLSELRSLQ DWFLKFELKT IPNVAEVASV 
181:	GGVVKQYQIQ VNPVKLSQYG ISLPEVKQAL ESSNQEAGGS SVEIAEAEYM VRASGYLQSI 
241:	DDFNNIVLKT GENGVPVYLR DVARVQTGPE MRRGIAELNG QGEVAGGVVI LRSGKNARDV 
301:	ITAVRDKLET LKASLPEGVE IVTTYDRSQL IDRAIDNLSS KLLEEFFVVA IVCALFLWHV 
361:	RSALVAIISL PLGLCIAFIV MHFQGLNANI MSLGGIAIAV GAMVDAAIVM IENAHKRLEE 
421:	WDHRHPGEQI DNVTRWKVIT DASVEVGPAL FISLLIITLS FIPIFTLEGQ EGRLFGPLAF 
481:	TKTYSMAGAA ALAIIVIPIL MGFWIRGKIP AETSNPLNRV LIKAYHPLLL RVLHWPKTTL 
541:	LVAALSIFTV VWPLSQVGGE FLPKINEGDL LYMPSTLPGV SPAEAAALLQ TTDKLIKSVP 
601:	EVASVFGKTG KAETATDSAP LEMVETTIQL KPEDQWRPGM TIDKIIDELD RTVRLPGLAN 
661:	LWVPPIRNRI DMLSTGIKSP IGIKVSGTVL SDIDATAQSI EAVAKTVPGV VSVLAERLEG 
721:	GRYIDIDINR EKASRYGMTV GDVQLFVSSA IGGAMVGETV EGVARYPINI RYPQDYRNSP 
781:	QALKQMPILT PMKQQITLGD VADINVVSGP TMLKTENARP ASWIYVDARG RDMVSVVNDI 
841:	KTAISEKVKL RPGTSVAFSG QFELLEHANK KLKLMVPMTV MIIFILLYLA FRRVDEALLI 
901:	LMSLPFALVG GIWFLYWQGF HMSVATGTGF IALAGVAAEF GVVMLMYLRH AIEAHPELSR 
961:	KETFTPEGLD EALYHGAVLR VRPKAMTVAV IIAGLLPILW GTGAGSEVMS RIAAPMIGGM 
1021:	ITAPLLSLFI IPAAYKLIWL RRHKKSVS