TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.6.2.15
Multidrug efflux pump, MexD (exports β-lactams, fluoroquinolones, tetracycline, macrolides, chloramphenicol, biocides, including levofloxacin, carbenicillin, aztreonam, ceftazidime, cefepime, cefoperazone, piperacillin, erythromycin, azithromycin, chloramphenicol, etc.; Mao et al., 2002). Functions with MexC (MFP) and OprJ (OMF) (Mao et al., 2002; Poole, 2008).

Accession Number:Q9HVI9
Protein Name:MexD aka PA4598
Length:1043
Molecular Weight:111595.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Beta-lactams, Fluoroquinolones, tetracycline, Macrolides, Chloramphenicol, Levofloxacin, Carbenicillin, Aztreonam, Ceftazidime, Cefepime, Cefoperazone, Piperacillin, erythromycin, Azithromycin

Cross database links:

HEGENOM: HBG293864
RefSeq: NP_253288.1   
Entrez Gene ID: 881071   
Pfam: PF00873   
BioCyc: PAER208964:PA4598-MONOMER   
KEGG: pae:PA4598   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSEFFIKRPN FAWVVALFIS LAGLLVISKL PVAQYPNVAP PQITITATYP GASAKVLVDS 
61:	VTSVLEESLN GAKGLLYFES TNNSNGTAEI VVTFEPGTDP DLAQVDVQNR LKKAEARMPQ 
121:	AVLTQGLQVE QTSAGFLLIY ALSYKEGAQR SDTTALGDYA ARNINNELRR LPGVGKLQFF 
181:	SSEAAMRVWI DPQKLVGFGL SIDDVSNAIR GQNVQVPAGA FGSAPGSSAQ ELTATLAVKG 
241:	TLDDPQEFGQ VVLRANEDGS LVRLADVARL ELGKESYNIS SRLNGTPTVG GAIQLSPGAN 
301:	AIQTATLVKQ RLAELSAFFP EDMQYSVPYD TSRFVDVAIE KVIHTLIEAM VLVFLVMFLF 
361:	LQNVRYTLIP SIVVPVCLLG TLMVMYLLGF SVNMMTMFGM VLAIGILVDD AIVVVENVER 
421:	IMAEEGISPA EATVKAMKQV SGAIVGITLV LSAVFLPLAF MAGSVGVIYQ QFSVSLAVSI 
481:	LFSGFLALTF TPALCATLLK PIPEGHHEKR GFFGAFNRGF ARVTERYSLL NSKLVARAGR 
541:	FMLVYAGLVA MLGYFYLRLP EAFVPAEDLG YMVVDVQLPP GASRVRTDAT GEELERFLKS 
601:	REAVASVFLI SGFSFSGQGD NAALAFPTFK DWSERGAEQS AAAEIAALNE HFALPDDGTV 
661:	MAVSPPPING LGNSGGFALR LMDRSGVGRE ALLQARDTLL GEIQTNPKFL YAMMEGLAEA 
721:	PQLRLLIDRE KARALGVSFE TISGTLSAAF GSEVINDFTN AGRQQRVVIQ AEQGNRMTPE 
781:	SVLELYVPNA AGNLVPLSAF VSVKWEEGPV QLVRYNGYPS IRIVGDAAPG FSTGEAMAEM 
841:	ERLASQLPAG IGYEWTGLSY QEKVSAGQAT SLFALAILVV FLLLVALYES WSIPLSVMLI 
901:	VPIGAIGAVL AVMVSGMSND VYFKVGLITI IGLSAKNAIL IVEFAKELWE QGHSLRDAAI 
961:	EAARLRFRPI IMTSMAFILG VIPLALASGA GAASQRAIGT GVIGGMLSAT FLGVLFVPIC 
1021:	FVWLLSLLRS KPAPIEQAAS AGE