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2.A.6.2.16
Multidrug efflux pump, MexF (exports fluoroquinolones, chloramphenicol, biocides, xenobiotics and chloramphenicol; functions with MexE (MFP) and OprN (OMF)) (Kohler et al., 1997; Poole, 2008).  The P. putida orthologue also exports solvents such as farnesyl hexanoate (Dunlop et al. 2011).

Accession Number:Q9I0Y8
Protein Name:MexF
Length:1062
Molecular Weight:115510.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Fluoroquinolones, Chloramphenicol, Biocides, Farnesyl hexanoate

Cross database links:

HEGENOM: HBG293864
RefSeq: NP_251184.1   
Entrez Gene ID: 882884   
Pfam: PF00873   
BioCyc: PAER208964:PA2494-MONOMER   
KEGG: pae:PA2494   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNFSQFFIQR PIFAAVLSLL ILIGGAISLF QLPISEYPEV VPPTVVVRAN FPGANPKVIG 
61:	ETVASPLEQA ITGVENMLYM SSQSTSDGKL TLTITFALGT DLDNAQVQVQ NRVTRTEPKL 
121:	PEEVTRLGIT VDKASPDLTM VVHLTSPDNR YDMLYLSNYA VLNVKDELAR LDGVGDVQLF 
181:	GLGDYSLRVW LDPNKVASRN LTATDVVNAI REQNRQVAAG TLGAPPAPSD TSFQLSINTQ 
241:	GRLVTEEEFE NIIIRAGANG EITRLRDIAR VELGSNQYAL RSLLNNKPAV AIPIFQRPGS 
301:	NAIEISNLVR EKMAELKHSF PQGMDYSIVY DPTIFVRGSI EAVVHTLFEA LVLVVLVVIL 
361:	FLQTWRASII PLAAVPVSLI GTFAVMHMLG FSLNALSLFG LVLAIGIVVD DAIVVVENVE 
421:	RNIGLGLKPV EATKRAMREV TGPIIATALV LCAVFIPTAF ISGLTGQFYR QFALTIAIST 
481:	VISAFNSLTL SPALAAVLLK GHHEPKDRFS VFLDKLLGSW LFRPFNRFFD RASHGYVGTV 
541:	NRVLRGSSIA LLVYGGLMVL TYFGFSSTPT GFVPQQDKQY LVAFAQLPDA ASLDRTEAVI 
601:	KQMSEIALAQ PGVADSVAFP GLSINGFTNS PNSGIVFTPL KPFDERKDPS QSAGAIAAAL 
661:	NAKYADIQDA YIAIFPPPPV QGLGTIGGFR LQIEDRGNQG YEELFKQTQN IITKARALPE 
721:	LEPSSVFSSY QVNVPQIDAD IDREKAKTHG VAISDIFDTL QVYLGSLYAN DFNRFGRTYQ 
781:	VNVQAEQQFR LEPEQIGQLK VRNNLGEMVP LASFIKVSDT SGPDRVMHYN GFITAELNGA 
841:	PAAGYSSGQA QAAIEKLLKE ELPNGMTYEW TELTYQQILA GNTALFVFPL CVLLAFLVLA 
901:	AQYESWSLPL AVILIVPMTL LSAITGVILA GSDNNIFTQI GLIVLVGLAC KNAILIVEFA 
961:	KDKQEEGMDR VAAVLEACRL RLRPILMTSI AFIMGVVPLV ISTGAGAEMR HAMGVAVFSG 
1021:	MIGVTFFGLL LTPVFYVLIR RFVENREARR AANDKGLPEV HA