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2.A.6.2.17
Multidrug efflux pump, MexK (exports fluoroquinolones, macrolides, chloramphenicol; biocides, and triclosan [with MexJ but without OprM] as well as tetracycline, erythromycin [requiring both MexJ and OprM]; Chuanchuen et al., 2002). Can function with OpmH (BAC24099) instead of OprM (Poole, 2008).

Accession Number:Q9HXW4
Protein Name:MexK
Length:1025
Molecular Weight:113277.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Fluoroquinolones, tetracycline, Macrolides, Chloramphenicol, Biocides, Triclosan, erythromycin

Cross database links:

HEGENOM: HBG677732
RefSeq: NP_252366.1   
Entrez Gene ID: 879602   
Pfam: PF00873   
BioCyc: PAER208964:PA3676-MONOMER   
KEGG: pae:PA3676   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSFNLSAWAL QNRQIVLYLM ILLGAVGALS YSKLGQSEDP PFTFKAMVVQ TNWPGASAEE 
61:	VARQVTERIE KKLMETGDYD RIVSFSRPGV SQVTFMARED IHSSEIPELW YQIRKKISDI 
121:	RATLPQSIQG PFFNDEFGTT YGNIYALTGK GFDYAVMKDY ADRLQLQLQR IRNVGKVELI 
181:	GLQDEKIWID LSNTKLATLG LPLAAVQKAL EEQNAVASSG FFETASDRVQ LRVSGRFDSV 
241:	EEIRDFPIRV GDRTFRIGDV AEVRRGFNDP PAPRMRFMGE DAIGLAVAMK PGGDILVLGK 
301:	ALETEFARLQ QSLPAGLELR KVSDQPAAVR TGVGEFIRVL AEALVIVLLV SFFSLGLRTG 
361:	LVVALSIPLV LAMTFAAMHY FGIGLHKISL GALVLALGLL VDDAIIAVEM MAVKMEQGYD 
421:	RLKAASFAWT STAFPMLTGT LITAAGFLPI ATAQSGTGEY TRSLFQVVTI ALVVSWFAAV 
481:	VFVPYLGAKL LPDLARLHAQ KHGGSADGYD PYATAFYQRF RRLVEWCVRY RKTVIVLTLA 
541:	AFVGALLLFR LVPQQFFPPS ARLELLLDIK LAEGASLRST GEEVQRLEKM LQGHDGIDNY 
601:	VAYVGTGSPR FYLPLDQQLP AASFAQVVVL AKDLESREAL RKWLIERMNE DFPHLRSRIS 
661:	RLENGPPVGY PVQFRVSGED IPQVRELARK VADKMRENPH VVNVHLDWEE PSKVVYLSID 
721:	QERARALGVS TASLSQFLQS ALTGSHVSFF REDNELIEIL LRGTEQERRD LSLLPSLAVP 
781:	TENGRSVALS QIATLEYGFE EGIIWHRNRL PTVTVRADIY DDSLPATLVA QIAPTLEPIR 
841:	AELPDGYLLE VGGTVEDAAK GQSSVNAGVP LFIVVVLSLL MVQLRSFSRM AMVFLTAPLG 
901:	LIGVTLFLLL FRQPFGFVAM LGTIALAGMI MRNSVILVDQ IEQDISHGLD RWHAIIEATV 
961:	RRFRPIVLTA LAAVLAMIPL SRSVFFGPMA VAIMGGLIVA TVLTLLFLPA LYAAWFRVKK 
1021:	DEARA