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2.A.6.2.33
Multidrug efflux pump, MexVW OmpM (exports fluoroquinolones, macrolides, chloramphenicol, and tetracycline) (Poole, 2008).

Accession Number:Q9HW27
Protein Name:PA4375
Length:1018
Molecular Weight:110532.00
Species:Pseudomonas aeruginosa GN=PA4375 PE=4 SV=1 [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type I membrane protein2
Substrate Fluoroquinolones, Macrolides, Chloramphenicol, tetracycline

Cross database links:

HEGENOM: HBG293864
RefSeq: NP_253065.1   
Entrez Gene ID: 881377   
Pfam: PF00873   
BioCyc: PAER208964:PA4375-MONOMER   
KEGG: pae:PA4375   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAFTDPFIRR PVLASVVSLL IVLLGMQAFS KLVIREYPQM ENALITVTTL YAGANAETIQ 
61:	GYITQPLQQS LASAEGIDYM TSVSRQNYST ISIYARIGAN TDRLVTELLA KSNEVKSQLP 
121:	PDAEDPVLQK EAADASALMY ISFYSEQMNN PQITDYLSRV IQPKLATLPG IAEAEILGNQ 
181:	VFAMRLWLDP VKMAAFGVTA GEINQAVQQY NFLAAAGEVK GQLVVTSVNA STDLKSPQAF 
241:	AAIPVKTDGD RRVLMGDVAR VELGAASYDA ISSFNGIPSV YIGIKGTPSA NPLDVIKEVR 
301:	AKMPELEEQL PPNLKVSIAY DATRFIQASI DEVVKTLGEA VLIVIVVVFL FLGAFRSVLI 
361:	PVVTIPLSMI GVLFFMQAMG YSINLLTLLA MVLAIGLVVD DAIVVVENIH RHIEEGKPPF 
421:	EAALEGAREI AVPVVSMTIT LAAVYAPIGF LTGLTGALFK EFAFTLAGAV IISGIVALTL 
481:	SPMMCSRLLR HEENPSGLAH RLDLIFEGLK QRYQRALHGT LDTRPVVLVF AVLVLALIPV 
541:	LLMFTKKELA PEEDQGIVFL MTNSPQTANL DYLNRYTAEF EGIFRSFPEY YSAFQINGYN 
601:	GVQAGIGGML LKPWDEREKS QMELLHAVQA KLNEIPGVQI FAFNLPSLPG TGEGLPFQFV 
661:	LNTANDYESL LQVAQRVKQR ASESGKFAFL DLDLAFDKPE LVVDIDREKA AQMGVSMQDL 
721:	GVALASLLGE GEINRFTIDG RSYKVIAQVE RPYRDNPGWL GSYYVKSRNG QLVALSTLIE 
781:	THERARPRQL NQFQQLNSAI ISGFPIVSMG EAIETVQQIA REEAPRGFAV DYAGASRQYV 
841:	QEGSALLVTF GLALAIIFLV LAAQFESFRD PLVIMVTVPL SICGALIPLF LGVSSLNIYT 
901:	QVGLVTLIGL ISKHGILIVE FANQLRHEQG LGRREAIEQA AAIRLRPVLM TTAAMVLGVI 
961:	PLILATGAGA VSRFDIGIVI ATGMSVGTLF TLFVLPCIYT LVARPDAPPG VTQAANAH