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2.A.6.2.48
Multidrug resistance (MDR) pump, AcrD, AcrF, Env.  Catalyzes efflux of various hydrophilic and amphipathic drugs including clotrimazole and luteolin, but not aminoglycosides.  Induction of acrD expression occurs in infected apple tissue but not in pear tissues.  Regulated by the two component BaeSR sensor kinase/response regulator (Pletzer and Weingart 2014).

Accession Number:E3DBE3
Protein Name:Acriflavine resistance protein B
Length:1037
Molecular Weight:112689.00
Species:Erwinia sp. (strain Ejp617) [215689]
Number of TMSs:12
Substrate Clotrimazole, Luteolin

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANFFIDRPI FAWVLAILLC LTGGLAIVSL PIEQYPDLAP PNVRITANYP GASAETLENT 
61:	VTQVIEQNMT GLDNLMYMSS QSSHTGQATV TLTFEAGTNP DEARQQVQNQ LQTALRKLPQ 
121:	DVQAQGVNVN KTGDTNILMV AFVSTDGSMD KQDIADYVAS HLQDPLSRIN GVGQVDAYGS 
181:	QYAMRIWLDP NKLINYALTT TEVVDAIKSQ NSQVAVGQLG GLPSVDRQAL NATINAQSLL 
241:	QTPQQFRAIT LKVNADGSVV TLGQVAQVAL GAEKYDYLSR YNGMAASGLG IKLASGANEL 
301:	QTDKLVRARL DELSRFFPHG LQAEIAFETS PFVKASIEDV VKTLFEAVLL VFLVMYLFLQ 
361:	NFRATLIPTI AVPVVLFGTF GVLYAFGYSI NTLTMFAMVL AIGLLVDDAI VVVENVERIM 
421:	TEEGLSPRDA TRKSMGQIQG ALVGIALVLS AVFVPMAFFG GTTGAIYRQF SVTIVSAMVL 
481:	SVLVAMILTP ALCCTLLKPL AMGHHHGQRG FFGWFNRTFN HNAERYKRGV GRMLVKGGRW 
541:	LVVYLALIAV MALLFMRLPT SFLPLEDRGL FTTQVQLPPG STLQQTMTVV EKVEHYYLTH 
601:	EQDNVQSVFA TVGAGPGGNG QNVARLFVRL KDWQNRLGSD NTSFAIIDRA TKAFSRINEA 
661:	KVVASSPSAI TGLGNSAGFD MELQDNAGLG HRALMNARNT LLEMAQKNPS LTRVRHNGLD 
721:	DSPQLRIDID QRKAQTLGVS LHDINATLQT GWGSTYVNDF LDRGRVKKVY VQADAPFRML 
781:	PDDISKWYVR NASGGMVPFT AFARSHWENG SPRLERYNGY PALEIVGESA AGVSNGAAMD 
841:	MMEKLVSQLP NGIGLQWTGA SLQERMTGAQ APALYALSLL VVFLCLAALY ESWSIPFSVM 
901:	LVVPLGVLGA LIATWLRGLE NDVYFQVGLL TVVGLSAKNA ILIVEFANEI NSRGSELMAA 
961:	TLEAARQRLR PILMTSLAFI FGVLPMAISQ GAGSSSQHAV GTGVLGGMIS ATVLAIFFVP 
1021:	LFFVLVRRRF PLKDKPQ