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2.A.6.4.2
Protein translocase subunit SecDF

Accession Number:O32047
Protein Name:Protein translocase subunit SecDF
Length:737
Molecular Weight:81654.00
Species:Bacillus subtilis (strain 168) [224308]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

eggNOG: COG0341
HEGENOM: HOG000018636
Entrez Gene ID: 937938   
Pfam: PF07549    PF02355   
KEGG: bsu:BSU27650   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005622 C:intracellular
GO:0005886 C:plasma membrane
GO:0015450 F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0006886 P:intracellular protein transport

References (4)

[1] “SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins.”  Bolhuis A.et.al.   9694879
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Translocation of proteins across the cell envelope of Gram-positive bacteria.”  van Wely K.H.M.et.al.   11524133
[4] “Localization of translocation complex components in Bacillus subtilis: enrichment of the signal recognition particle receptor at early sporulation septa.”  Rubio A.et.al.   15995216

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKGRLIAFF LFVLLIGTGL GYFTKPAANN ITLGLDLQGG FEVLYDVQPV KKGDKITKDV 
61:	LVSTVEALNR RANVLGVSEP NIQIEGNNRI RVQLAGVTNQ NRAREILATE AQLSFRDAND 
121:	KELLNGADLV ENGAKQTYDS TTNEPIVTIK LKDADKFGEV TKKVMKMAPN NQLVIWLDYD 
181:	KGDSFKKEVQ KEHPKFVSAP NVSQELNTTD VKIEGHFTAQ EAKDLASILN AGALPVKLTE 
241:	KYSTSVGAQF GQQALHDTVF AGIVGIAIIF LFMLFYYRLP GLIAVITLSV YIYITLQIFD 
301:	WMNAVLTLPG IAALILGVGM AVDANIITYE RIKEELKLGK SVRSAFRSGN RRSFATIFDA 
361:	NITTIIAAVV LFIFGTSSVK GFATMLILSI LTSFITAVFL SRFLLALLVE SRWLDRKKGW 
421:	FGVNKKHIMD IQDTDENTEP HTPFQKWDFT SKRKYFFIFS SAVTVAGIII LLVFRLNLGI 
481:	DFASGARIEV QSDHKLTTEQ VEKDFESLGM DPDTVVLSGE KSNIGVARFV GVPDKETIAK 
541:	VKTYFKDKYG SDPNVSTVSP TVGKELARNA LYAVAIASIG IIIYVSIRFE YKMAIAAIAS 
601:	LLYDAFFIVT FFSITRLEVD VTFIAAILTI IGYSINDTIV TFDRVREHMK KRKPKTFADL 
661:	NHIVNLSLQQ TFTRSINTVL TVVIVVVTLL IFGASSITNF SIALLVGLLT GVYSSLYIAA 
721:	QIWLAWKGRE LKKDSAQ