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2.A.6.5.10
Multidrug resistance protein, CmpL1, of 772 aas and 12 TMSs. Mutants are hypersusceptible to multiple antibiotics, have growth deficiencies in minimal medium and accumulate intracellular trehalose monocorynomycolates, free corynomycolates, and a previously uncharacterized corynomycolate-containing lipid.  It is inferred that this transporter exports one or more of these lipids.  Evidence for a pmf-dependent mechanism was obtained (Yang et al. 2014).

Accession Number:Q8NLS1
Protein Name:Predicted drug exporters of the RND superfamily
Length:772
Molecular Weight:83056.00
Species:Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [196627]
Number of TMSs:12
Substrate drugs

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFSKWGHFAY RFRRIVPLVV IAAILALFVI FGTKLGDRMS QEGWDDPGSS STAAARIELE 
61:	TFGRDNDGDV VLLFTAPEGT SFDDAEVFSS ISGYLDGLIE NNPDEVSHIN SYFDTRNQNL 
121:	LSKDGTQTFA ALGLKGDGEQ TLKDFREIED QLHPDNLAGG VTTEVAGATA VADALDEGMA 
181:	GDISRAEVFA LPFVAILLLI VFGSVVAAAM PLIVGILSIL GSLGILAILA GFFQVNVFAQ 
241:	SVVTLLGLGL AIDYGLFMVS RFREEMDKGT PVEQAVATTT ATAGKTVVFS AAMVAVALSG 
301:	LFVFPQAFLK SVAFGAISAV GLAALMSVTV LPSLFSMLGK NIDKWSLRRT ARTARRLEDT 
361:	IWYRVPAWAM RHAKAVTVGV VLLLLALTVP LTGVKFGGIN ETYLPPANDT RVAQERFDEA 
421:	FPAFRTEPVK LVVTGADNNQ LIDIYVQANE VEGLTDRFTA GATTDDGTTV LSTGIQDRSL 
481:	NEQVVEQLRA ISVPEGVEVQ IGGTPAMEIE SIEALFEKLL WMALYIVLAT FILMALVFGS 
541:	VILPAKAIIM TILGMGATLG ILTLMFVDGV GASALNFSPG PLMSPVLVLI MAIIYGLSTD 
601:	YEVFLVSRMV EARDKGESTD DAIRYGTAHT GSIITAAALI MIVVCGAFGF SEIVMMKYIA 
661:	FGMIAALILD ATIIRMLLVP AVMHLLRDDN WWAPGFVKKA YTVMGHGSEV EEAPRPTTRR 
721:	LNDDEEVTVH EAVVAGDTVA SRGGLSTQEN RDLVSFVELK ARLEKRRLED LD