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2.A.6.5.11
CmpL4 of 801 aas and 12 TMSs.  Multidrug resistance protein of 801 aas and 12 TMSs. Mutants are hypersusceptible to multiple antibiotics, have growth deficiencies in minimal medium and accumulate intracellular trehalose monocorynomycolates, free corynomycolates, and a previously uncharacterized corynomycolate-containing lipid.  It is inferred that this transporter exports one or more of these lipids.  Evidence for a pmf-dependent mechanism was obtained (Yang et al. 2014).

Accession Number:Q8NTS1
Protein Name:Predicted drug exporters of the RND superfamily
Length:801
Molecular Weight:85801.00
Species:Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [196627]
Number of TMSs:12
Substrate drugs

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKLLFRLGR WSYNRKWIVI SAWLLILAIV GGLALTMQKG FSNSFTIEDT PSIDATVSLV 
61:	ENFPDQTNPV TAAGVNVVFQ SPEGTTLDDP QMMTAMDAVV DYIEDNLPDF GGGERFGNPV 
121:	EVSPALEEMV IEQMTSMGLP EETAAKDAAN LAVLSEDKTI GYTSFNIDVE AAEYVEQKHR 
181:	DVINEAMQIG EDLGVRVEAG GPAFGDPIQI ETTSEIIGIG IAFIVLIFTF GSLIAAGLPL 
241:	ITAVIGVGIG ALAIVLATAF TDLNNVTPVL AVMIGLAVGI DYALFILSRY RAEYKRMPRA 
301:	DAAGMAVGTA GSAVVFAGAT VIIALVALII ADIGFLTAMG ISAAFTVFVA VLIALTFIPA 
361:	LLGVFGGHAF KGKIPGIGGN PTPKQTWEQA LNRRSKGRSW VKLVQKAPGL VVAVVVLGLG 
421:	ALTIPAMNLQ LSLPSDSTSN IDTTQRQSAD LMAEGFGAGV NAPFLVIVDT HEVNADSTAL 
481:	QPLIEAQEPE EGEFDREQAA RFATYMYVTQ TYNSNIDVKN AQIISVNDDF TAAQILVTPY 
541:	TGPADKETPE LMHVLRAQEA QIEDVTGTEL GTTGFTAVQL DITEQLEDAM PVYLAVVVGL 
601:	AIFLLILVFR SLLVPLVAGL GFLLSVGAAF GATVLVWQEG FGGFVNTPGP LISFMPIFLI 
661:	GVTFGLAMDY QVFLVTRMRE HYTHHNGKGQ PGSKYTPVEQ SVIEGFTQGS RVVTAAALIM 
721:	IAVFVAFIDQ PLPFIKIFGF ALGAGVFFDA FFIRMGLVPA SMFLMGKATW WMPKWLDRIL 
781:	PSLDIEGTAL EKEWEEKQAA R