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2.A.6.5.12
MmpL4a of 959 aas and 12 TMSs.  A rough morphotype has a Y842H mutation that causes a deficiency in glycopeptidolipid production and a gain in the capacity to produce cords in vitro. In zebrafish, increased virulence of the M. bolletii R variant over the parental S strain was noted, involving massive production of serpentine cords, abscess formation and rapid larval death. Tyr842 is conserved in several MmpL proteins (Bernut et al. 2016).

Accession Number:A5A9P9
Protein Name:Membrane protein
Length:959
Molecular Weight:104113.00
Species:Mycobacterium chelonae [1774]
Number of TMSs:12
Substrate Unknown

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSESDGKGQS HRPIMATIIR KGAVFIILGW LAITVLLTVK VPPLEIVERE HSVSLSPPDA 
61:	PSVKAMTQMG KVFQESNSES VAVIVLEGEN PLGDDAHKYY DAVVRQLKDD PKHVQHIQDF 
121:	WGDPLTAGAA QSADGKAAYV QLNLTGRFGQ ADANESVEAV QKIVKDTPGL PPGVKTYVTG 
181:	PAAVVSDMSE SGNRTVILIT LVSVGVIFLM LLLLYRSFIT VIILLFTVGI ELQVARGLVA 
241:	FLGMHGIVGL TTFVVNLLVS VGIAAGTDYG IFFTGRYQEA RQAGEDRQTA YYTAYRGVAK 
301:	VVLASGLTIA GAIACLHFTR LPYFKPLGIP GAVGILVAVA VALTLVPACI AAGSRFGLFD 
361:	PKRQVTTRRW RRLGTAIVRW PGPILAGTVA ISLIGLLTLP GYNPSYTDAK YIPKDIPAVQ 
421:	GLVAASRHFP ESKMSTPDIL LVEANHDMRN SADLLVLNRL AKAVFAVPGI ANVQSITRPE 
481:	GTQIEHSSVP FMLSMSNASQ RLSLPFQRAR MDDMLKQADD MGTTIALMQR MFDLMKQMVA 
541:	TTHRMVSTTH DLQKDMSTLR DHIENFEDFW RPIRNYFYWE KHCFDIPICW SIRSIFDALD 
601:	GVDQVTDKMQ TLVGDLDELD RLMPQLLEQF PIMIDTMKST RESMLTMHST MSGIFAQMDE 
661:	STENSTAMGK AFDASKNDDS FYLPPDVLNN KDFKRVMKIF MSPDGKSTRM LISQRGDPAT 
721:	PEGIARVDPI KTAAEEALKG TPLEHAKISL AGTAAGVSEL VDGSKYDLLI AGVAALCLIF 
781:	IIMLLMTRSL VAALVIVGTV ALSLGASFGL SVLVWQHICG IQINWVVLAM SVIVLLAVGS 
841:	DYNLLLVSRM KEELGAGLNT GIIRAMGGTG KVVTAAGLVF AATMGSMIVS DLLTLGQVGT 
901:	TIGLGLLFDT LIVRAFMTPA IAALLGRWFW WPLQVSPRPV GAVHGWKGPR LVRSVLQRN