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2.A.6.5.4
sulfolipid, 2,3-diacyl-α, α'-D-trehalose-2'-sulfate (sulfatide precursor) exporter, MmpL8 (Domenech et al., 2004; Seeliger et al. 2012Seeliger et al. 2012).

Accession Number:O07800
Protein Name:2,3-diacyl-Éø, Éø'-D-trehalose-2'-sulfate (sulfatide precursor) exporter, MmpL8
Length:1089
Molecular Weight:115998.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate 2,3-diacyl-alpha, alpha'-D-trehalose-2'-sulfate

Cross database links:

HEGENOM: HBG567289
RefSeq: NP_218340.1    NP_338484.1   
Entrez Gene ID: 886145    922579   
KEGG: mtc:MT3931    mtu:Rv3823c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006869 P:lipid transport

References (7)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.”  Converse S.E.et.al.   12724526
[4] “The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis.”  Domenech P.et.al.   15001577
[5] “Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance.”  Domenech P.et.al.   15908378
[6] “The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis.”  Walters S.B.et.al.   16573683
[7] “targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.”  Raman K.et.al.   19099550

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MCDVLMQPVR TPRPSTNLRS KPLRPTGDGG VFPRLGRLIV RRPWVVIAFW VALAGLLAPT 
61:	VPSLDAISQR HPVAILPSDA PVLVSTRQMT AAFREAGLQS VAVVVLSDAK GLGAADERSY 
121:	KELVDALRRD TRDVVMLQDF VTTPPLRELM TSKDNQAWIL PVGLPGDLGS TQSKQAYARV 
181:	ADIVEHQVAG STLTANLTGP AATVADLNLT GQRDRSRIEF AITILLLVIL LIIYGNPITM 
241:	VLPLITIGMS VVVAQRLVAI AGLAGLGIAN QSIIFMSGMM VGAGTDYAVF LISRYHDYLR 
301:	QGADSDQAVK KALTSIGKVI AASAATVAIT FLGMVFTQLG ILKTVGPMLG ISVAVVFFAA 
361:	VTLLPALMVL TGRRGWIAPR RDLTRRFWRS SGVHIVRRPK THLLASALVL VILAGCAGLA 
421:	RYNYDDRKTL PASVESSIGY AALDKHFPSN LIIPEYLFIQ SSTDLRTPKA LADLEQMVQR 
481:	VSQVPGVAMV RGITRPAGRS LEQARTSWQA GEVGSKLDEG SKQIAVHTGD IDKLAGGANL 
541:	MASKLGDVRA QVNRAISTVG GLIDALAYLQ DLLGGNRVLG ELEGAEKLIG SMRALGDTID 
601:	ADASFVANNT EWASPVLGAL DSSPMCTADP ACASARTELQ RLVTARDDGT LAKISELARQ 
661:	LQATRAVQTL AATVSGLRGA LATVIRAMGS LGMSSPGGVR SKINLVNKGV NDLADGSRQL 
721:	AEGVQLLVDQ VKKMGFGLGE ASAFLLAMKD TATTPAMAGF YIPPELLSYA TGESVKAETM 
781:	PSEYRDLLGG LNVDQLKKVA AAFISPDGHS IRYLIQTDLN PFSTAAMDQI DAITAAARGA 
841:	QPNTALADAK VSVVGLPVVL KDTRDYSDHD LRLIIAMTVC IVLLILIVLL RAIVAPLYLI 
901:	GSVIVSYLAA LGIGVIVFQF LLGQEMHWSI PGLTFVILVA VGADYNMLLI SRLREEAVLG 
961:	VRSGVIRTVA STGGVITAAG LIMAASMYGL VFASLGSVVQ GAFVLGTGLL LDTFLVRTVT 
1021:	VPAIAVLVGQ ANWWLPSSWR PATWWPLGRR RGRAQRTKRK PLLPKEEEEQ SPPDDDDLIG 
1081:	LWLHDGLRL