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2.A.6.5.8
Siderophore exporter, MmpL5.  Functions with MmpS5, and both proteins are essential for transport activitiy (Wells et al. 2013). Together with MmpS5, it also pumps drugs out of the cell, and upregulation gives rise to drug resistance (Briffotaux et al. 2017).

Accession Number:O53784
Protein Name:Putative membrane protein mmpL5
Length:964
Molecular Weight:104785.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Siderophores

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  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIVQRTAAPT GSVPPDRHAA RPFIPRMIRT FAVPIILGWL VTIAVLNVTV PQLETVGQIQ 
61:	AVSMSPDAAP SMISMKHIGK VFEEGDSDSA AMIVLEGQRP LGDAAHAFYD QMIGRLQADT 
121:	THVQSLQDFW GDPLTATGAQ SSDGKAAYVQ VKLAGNQGES LANESVEAVK TIVERLAPPP 
181:	GVKVYVTGSA ALVADQQQAG DRSLQVIEAV TFTVIIVMLL LVYRSIITSA IMLTMVVLGL 
241:	LATRGGVAFL GFHRIIGLST FATNLLVVLA IAAATDYAIF LIGRYQEARG LGQDRESAYY 
301:	TMFGGTAHVV LGSGLTIAGA TFCLSFTRLP YFQTLGVPLA IGMVIVVAAA LTLGPAIIAV 
361:	TSRFGKLLEP KRMARVRGWR KVGAAIVRWP GPILVGAVAL ALVGLLTLPG YRTNYNDRNY 
421:	LPADLPANEG YAAAERHFSQ ARMNPEVLMV ESDHDMRNSA DFLVINKIAK AIFAVEGISR 
481:	VQAITRPDGK PIEHTSIPFL ISMQGTSQKL TEKYNQDLTA RMLEQVNDIQ SNIDQMERMH 
541:	SLTQQMADVT HEMVIQMTGM VVDVEELRNH IADFDDFFRP IRSYFYWEKH CYDIPVCWSL 
601:	RSVFDTLDGI DVMTEDINNL LPLMQRLDTL MPQLTAMMPE MIQTMKSMKA QMLSMHSTQE 
661:	GLQDQMAAMQ EDSAAMGEAF DASRNDDSFY LPPEVFDNPD FQRGLEQFLS PDGHAVRFII 
721:	SHEGDPMSQA GIARIAKIKT AAKEAIKGTP LEGSAIYLGG TAAMFKDLSD GNTYDLMIAG 
781:	ISALCLIFII MLITTRSVVA AAVIVGTVVL SLGASFGLSV LIWQHILGIE LHWLVLAMAV 
841:	IILLAVGADY NLLLVARLKE EIHAGINTGI IRAMGGSGSV VTAAGLVFAF TMMSFAVSEL 
901:	TVMAQVGTTI GMGLLFDTLI VRSFMTPSIA ALLGKWFWWP QVVRQRPIPQ PWPSPASART 
961:	FALV