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2.A.6.6.12
Niemann-Pick C1 protein, NPC1 of 1339 aas and 16 TMSs in a 1 + 3 + 1 +5 + 1 +5 arrangement. Trafficking of EhNPC1 and EhNPC2 during cholesterol uptake and phagocytosis as well as their association with molecules involved in endocytosis clearly suggest that these proteins play a key role in cholesterol uptake (Bolaños et al. 2016).

Accession Number:M3TK92
Protein Name:Niemann-Pick C1 protein, putative
Length:1339
Molecular Weight:152567.00
Species:Entamoeba histolytica HM-1:IMSS-B [885319]
Number of TMSs:15
Substrate cholesterol

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFVFFFLISV VISITPLPGG ERDINNLDQY NNKCRMHNVP GCTAPAINMK SDGTLYLTDA 
61:	YPAPKNMIEI CISEHPEFDP NVTLGHKTCC DEHSVLDLKE QSTLLDGSFG KCPACYLNQM 
121:	NLWCGFACDP NSARWTEIDD FKHDNTCNEP DGIDVPSLYY YLHPLYAQQI YDSCKDTELS 
181:	GGFAVRSLYP TYKEFFQMIS DVNPVMPLHF VYDETGYNGS KYTEMHKCSD MCSCQSCHEM 
241:	CTEFIEDEPT FKDYPFLDGT LNIITIISIH LFMLFIMVTI TVCGGILSYK TFTQMKKSNP 
301:	TLLYISYISL GAVTLLGIGF IIMGIIVVGF PMEGVITSMP WGDGNLLGMI LLYIGFGVYV 
361:	IGYSVYDLYY FVIYTLYNKK ESEDIIDSAK VSILGQEESC EEDPNKVDLT DNFLSKAMSW 
421:	YTKFLWKFKW IILTVVILCC IVLCVGVFKI VFITDSLGLW VPKNCQTMKD KNYYDEAFGP 
481:	FFRINQFMLS DKLHPGNQVL TQPLIVQLQQ MIDEIRAIHV EWTDKETGIT KDITMDDMCY 
541:	KPVFGKGCII TSVTGYWQHD INKIMNTENV TQYIQNCLGN PLATGCADDI GSPVDPHNSL 
601:	GNYTVGDNND PMKATILQAT FMFNQPNKTA IEWAELWEEK YLEILDRDYS LVKVAYQAQR 
661:	SVDDEINRET FTDVLTVLCS YMVMFIYISL SLGNSFYHFN YKTVFVKSRI LLGILGIVIV 
721:	LFSVFTSAGF FSWINVEATL IITEVIPFLV LAIGVDNIFI LTNTIDEQPM YDKDGQYVPV 
781:	EKRLEHSLMH VGPSMMLASI SESLAFFLGY LTSMPAVQSF SLYAGLAIFI DFILQITVYA 
841:	VLLCYDVKRQ ESHGLDFIPW LQVHDNSLDE QHDFERGSLI KHLFKYVATF LSYYPVKIIG 
901:	LFFFIAFFIF SLNYVPKTML GLPQETALPQ DSYIQDYFVA LTYLEIGPPV YIVVRDGATY 
961:	LNETTQSALC ASDNFGCDAL SIPNYYDAAR TIDGTTFDWI DDYFSWAAQK DCCRLDKDGN 
1021:	ICPYDMPNYT ECTPCFTNFT DKKRPVPEDF YKYINRFLTA SINETLCSVN GQAYYPDVVW 
1081:	NHINGTKETD YSYVNVSRLR LYHTVLVTQD DFIDAMVQAY NISDYMNSIF DVKTFPYAYH 
1141:	YVYFQQYFNI VDLCVMDVCL ALAAVFIVVM LLMFDPIVAI MIVLCVLMCV IDLIGIMYLW 
1201:	GVELNAVSCV NLVMSIGITI EFCVHIAHAF LSSPKKTLND KMKDAVMNMG NNVFVGITLT 
1261:	KFLGVIVLSL SSGLIFVIYY FRMYFMMLIF GASHGLFFLP ILLSLIPSVS LSHITDPFKK 
1321:	MFGRCNKKKS TKGEYQNFE