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2.A.6.6.7
Niemann-Pick C-type protein (NPC) (1342 aas; 16 putative TMSs in a 1+3+1+5+1+5 arrangement)

Accession Number:Q9TVK6
Protein Name:NPC1 protein
Length:1342
Molecular Weight:148023.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:16
Substrate cholesterol

Cross database links:

eggNOG: KOG1933
HEGENOM: HBG077178
Entrez Gene ID: 8617773   
Pfam: PF02460   
KEGG: ddi:DDB_G026915   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008158 F:hedgehog receptor activity
GO:0030301 P:cholesterol transport

References (1)

[1] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNINQIMSLF VCFCLFSSIY LINTVHSQGP FPYNTTEGCS MNGLNASYIE SGLYPPYHNQ 
61:	ILAPGTCQYS HPEYSETSCC TNGQTLVLLS NMVMGSAVFA RCPACLFNVW DLWCASSCSP 
121:	YQQSFMVPTS IDSKTGQILS VDFVIHPDYA WGLYNSCSGV NSDGAPPFGT IFHTPQDFFS 
181:	GIFALNPAFS INWVFNETGY ISPTAPCAES CSCDQCGDAC GPPPTVGEIG LFNNSLPQTY 
241:	LFNHEIPFLS VWMIWTFIMF TLVLTYGTSM GLVLFGNVKF FDSTKVKVIA SLVLSISFIS 
301:	AILIPFISGK VPLHDSSCQW KMPSDQLWNC SLALGVGIYE LITFIFLFVI SIVIIVLYHI 
361:	GSNNRPIPGS SSNASVVYDA LISSNSSNND NSNSNNNEQQ QQQPSTIIQR FFYWYGHKVA 
421:	SKPLIVILIC IIITAGLGIG IIKLEIEQDP VKLWVAPDSR AALDKTYFDN NFGPFYRVEQ 
481:	IIITPKNQTK YPTVIEYDLL LELFEIELSL MSLEAEYEGE LITLDSLCFK PTKRGCLIES 
541:	TSGLWQRNIS KLNYTQSEEG VLTYYENCQS SLLQPDCMDS VGAPVQPRVV LGGWENNNSS 
601:	AASAFVVTFL LNNPTDMVNT AMAWEQVWLD HISAIAATSE IFDITYSAER SVQDELSREG 
661:	NADIPTILIS YFVMFFYVSL SLGSYYPFPT RFLSLFVRSR FALGFCGIII VAASIVISVG 
721:	VCSMANLKAT LIISEVIPFL VLAIGVDNIF IIVNTFESLH VVRYDPHTRA AILPTSEDSL 
781:	ARTLAKVGPS IALASLSESL AFLLGSLTKM PAVQAFSYYA ALAIFVDFLL QVSAFSALLV 
841:	LDSKRASSRR IDCLPCIALE DGDNSDMEDD DDEENEKLPF ARADINANFK NSQPTYSTSS 
901:	SPKKTTLLQV VFKKFYAPFL LHPITKMLVI IFFVGLLLTG INFAFQVSIG LDQRVALPSN 
961:	SYLQGYFNNM ANLLEVGPPF YIVIKGDYNY TDFESQNKLC TMGGCDKDSI VNVFNNAPFI 
1021:	NKGISSWLDD YISFAQAQGS CCLKYPNGSI CYNGADPSCA PCFSNNAQGR PDPQSFIQYL 
1081:	PFFLNVSNTA SCPLAGLAYT SDAHIVNGTI VASRFDGYHT TLRTQDDYIN AVQTAYYLAD 
1141:	NSDLDVEVYS IIYVYFDQYL TIKSVAIMDI LLALGGVFIV CLILLLNPLV SFLVVISVGM 
1201:	ICVDLLGIMA LWNISLNAVS VVNVVMAIGI GIEFCVHIAS TFINAPKHFS RDQKAKYAVT 
1261:	EMGSSIISGI FITKLLGVVV LGFSTSEIFT VYYFRMYLSI VFLGGLHGLV FLPVLLSLFG 
1321:	TDTLQLDRLC KSKKNSYSLN DE