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2.A.6.6.8
Niemann-Pick C1 protein homologue-1, Ncr1; contains a sterol sensing domain. Catalyzes intracellular cholesterol release from endocytic organelles.

Accession Number:Q19127
Protein Name:Niemann-Pick C1 protein homolog 1
Length:1383
Molecular Weight:155457.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cholesterol

Cross database links:

eggNOG: NOG149152
HEGENOM: HBG388004
Entrez Gene ID: 180719   
Pfam: PF02460   
KEGG: cel:F02E8.6   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008158 F:hedgehog receptor activity
GO:0042632 P:cholesterol homeostasis
GO:0030301 P:cholesterol transport
GO:0040024 P:dauer larval development
GO:0009792 P:embryo development ending in birth or egg hatching
GO:0040010 P:positive regulation of growth rate
GO:0046662 P:regulation of oviposition

References (4)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans.”  Sym M.et.al.   10801441
[3] “Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.”  Loftus S.K.et.al.   9211850
[4] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKQLLIFCLL FGSIFHHGDA GCIMRGLCQK HTENAYGPCV TNDTNVEPTA FDKTHPAYEK 
61:	MVEFCPHLLT GDNKLCCTPS QAEGLTKQIA QARHILGRCP SCFDNFAKLW CEFTCSPNQQ 
121:	DFVSISEMKP IEKKEGFTPE YQPAEAYVNT VEYRLSTDFA EGMFSSCKDV TFGGQPALRV 
181:	MCTSTPCTLT NWLEFIGTQN LDLNIPIHTK FLLYDPIKTP PSDRSTYMNV NFTGCDKSAR 
241:	VGWPACSTSE CNKEEYANLI DLDDGKTSGQ TCNVHGIACL NIFVMLAFIG SLAVLLCVGF 
301:	VFTSYDEDYT NLRQTQSGEE SPKRNRIKRT GAWIHNFMEN NARDIGMMAG RNPKSHFFIG 
361:	CAVLIFCLPG MIYHKESTNV VDMWSSPRSR ARQEEMVFNA NFGRPQRYQQ IMLLSHRDFQ 
421:	SSGKLYGPVF HKDIFEELFD ILNAIKNIST QDSDGRTITL DDVCYRPMGP GYDCLIMSPT 
481:	NYFQGNKEHL DMKSNKEETV SEDDDAFDYF SSEATTDEWM NHMAACIDQP MSQKTKSGLS 
541:	CMGTYGGPSA PNMVFGKNST NHQAANSIMM TILVTQRTEP EIQKAELWEK EFLKFCKEYR 
601:	EKSPKVIFSF MAERSITDEI ENDAKDEIVT VVIALAFLIG YVTFSLGRYF VCENQLWSIL 
661:	VHSRICLGML SVIINLLSSF CSWGIFSMFG IHPVKNALVV QFFVVTLLGV CRTFMVVKYY 
721:	AQQRVSMPYM SPDQCPEIVG MVMAGTMPAM FSSSLGCAFS FFIGGFTDLP AIRTFCLYAG 
781:	LAVLIDVVLH CTIFLALFVW DTQRELNGKP EFFFPYQIKD LLGAYLIGRQ RATDTFMTQF 
841:	FHFQVAPFLM HRMTRIITGI IFIASFITTV ILSSKISVGF DQSMAFTEKS YISTHFRYLD 
901:	KFFDVGPPVF FTVDGELDWH RPDVQNKFCT FPGCSDTSFG NIMNYAVGHT EQTYLSGEMY 
961:	NWIDNYLEWI SRKSPCCKVY VHDPNTFCST NRNKSALDDK ACRTCMDFDY VANSYPKSSI 
1021:	MYHRPSIEVF YRHLRHFLED TPNSECVFGG RASFKDAISF TSRGRIQASQ FMTFHKKLSI 
1081:	SNSSDFIKAM DTARMVSRRL ERSIDDTAHV FAYSKIFPFY EQYSTIMPIL TTQLFITVVG 
1141:	VFGIICVTLG IDVKGAACAV ICQVSNYFHI VAFMYIFNIP VNALSATNLV MSSGILIEFS 
1201:	VNVLKGYACS LRQRAKDRAE STVGSIGPII LSGPVVTMAG STMFLSGAHL QIITVYFFKL 
1261:	FLITIVSSAV HALIILPILL AFGGSRGHGS SETSTNDNDE QHDACVLSPT AESHISNVEE 
1321:	GILNRPSLLD ASHILDPLLK AEGGIDKAID IITIDRSYPS TPSSLPCTSR MPRAHIEPDL 
1381:	RSL