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2.A.6.6.9
Niemann-Pick C1 protein homologue-2, Ncr2; contains a sterol sensing domain. Catalyzes intracellular cholesterol release from endocytic organelles.

Accession Number:P34389
Protein Name:Niemann-Pick C1 protein homolog 2
Length:1274
Molecular Weight:142634.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cholesterol

Cross database links:

eggNOG: NOG254241
HEGENOM: HBG044189
Entrez Gene ID: 176165   
Pfam: PF02460   
KEGG: cel:F09G8.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008158 F:hedgehog receptor activity
GO:0042632 P:cholesterol homeostasis
GO:0030301 P:cholesterol transport
GO:0040024 P:dauer larval development
GO:0040025 P:vulval development

References (3)

[1] “2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.”  Wilson R.et.al.   7906398
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans.”  Sym M.et.al.   10801441

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRQGGGGGER MVSVLFLLLI HLALCQAKCV MTECDGEEDS NHPPCKTNKS TYLPITVTRS 
61:	LNPTYMARFE KYCSYLVQEE DKAQVCCTEL QLKGMTDRIS NAATILGSCP SCFDNFAKLW 
121:	CQFTCSPDQS KFMKVMETTG PKNVVVKMEF KVNRDFVEGL YESCRHTWFA NGLALRLMSL 
181:	GGKVSFENFY GFMGTKNLAQ SIPINTEFQF SRMKNAMNIP TTPCHKSAGP KVPACGAIDC 
241:	PTNAHQLVDI SKVEHLGTKV FHPHFPDFEW LLKICGCLAL TVLLVFILKY SCHRRSAPNG 
301:	EDGCYVDLGK GNLEVQFEGL CARYANAVIK HPLIFVSLGL IVAAACCSGN FKFHSLTHSV 
361:	DQVSAADGET RRNEKKFIHS FGPNHRIEQI FINLPPTTKS MFNMPLFEEM FQLVGNIQNL 
421:	TACYGNSSVK LDDICYKPIG KNHGCAIMSP TNYFQNKWTN FENAGPPTID DEIFDDQHWE 
481:	HLKYCIRNPL TVSTYSEMSC FGEFSGPIDP ILVFGGSNES IKGAEMYYTA RTIMITVLIR 
541:	GPEDQAIAWE TAFLNMMSRY EMKHANFTFM TETSVAEEIH TAVETDKIVS VIACAAVLIW 
601:	VITMLGINHW PESSILSALV HHKLLISISA VMISVISVWC SIGMFSLFGV HATDNAIVVL 
661:	FFVITCLGIN RIFVIIRTFQ ANGHCYGLPN ISYREMNHRI SNVMRRSIPI VLTNSLICST 
721:	CLFLAGGVLP YVSVSMPAVE VFARHAGLAI LMDTAFYLLV MLPLFQYDAR REMSGKCEIW 
781:	PWYELSNESK INLCMEAVDG NLRSPVDWFK LAIAPLLLKK ICRIWIATFF FVSLIIACYC 
841:	TLCLEFGFNQ VMAFSETSYL TKHFQNMNEN LNIGPPLWFV VEGDVKWHDP KMQNKFCTLA 
901:	GCDDNSMGNK IRSLAYAENY KGNYLHGDVN IWLDSYLQFM HPRGSCCKMD GKQFCDPSNA 
961:	THCSSCSSSS VASLTTTEYE FYRNLHHFLE TPPSIQCAHG GMALAKPAIN LTRNGKIQSA 
1021:	YFSTFFKKLN LSDSIQLYDA WRFAKYLADD IERELEIPGV KVYVYSTFFP YYEQYLTLST 
1081:	TVYTLVVLVL FVAFVTISLF LRVNLAGSLV TVFVLLSSYL HLMEWMYLLG ITVNVVSVIN 
1141:	MAMSLGIAVE FFGQMLHGFY NSKKPKREER AFAALVSNGS TTLSGIFPAI MITAGCLSFA 
1201:	DSRVLITYFC NQLVGIGLVC AVHGVVYMPT LLAIFGSDFY QNVSSEEEST DEAELQDTPP 
1261:	STTSSTSSTS ETSV