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2.A.6.7.8
Hopanoid biosynthesis associated RND transporter like protein, HpnN of 877 aas and 12 TMSs. Hopanoid biosynthesis is one of the major mechanisms involved in multiple antimicrobial resistance of Bcc pathogens. The hpnN gene of B. multivorans encodes an integral membrane protein of the HpnN family of transporters, which is responsible for shuttling hopanoids to the outer membrane. Kumar et al. 2017 reported crystal structures of B. multivorans HpnN, revealing a dimeric molecule with an overall butterfly shape. Each subunit of the transporter contains 12 transmembrane helices and two periplasmic loops that suggest a plausible pathway for substrate transport. Further analyses indicated that HpnN is capable of shuttling hopanoid virulence factors from the outer leaflet of the inner membrane to the periplasm (Kumar et al. 2017).

Accession Number:J5C9U3
Protein Name:Hopanoid biosynthesis associated RND transporter like protein HpnN
Length:877
Molecular Weight:92736.00
Species:Burkholderia multivorans CF2 [985078]
Number of TMSs:13
Substrate

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FASTA formatted sequence
1:	MVTSLIVRLV AWSVRRPVWV VVLSLLIAAF SGVYVARHFK INTDISKLVD AEPQWAALSQ 
61:	AVDRAFPQRN GTILAVVEAP APEFATAAAH ALTESLQKQA AAGRIGPVAE PGGGPFFEHN 
121:	GLLFLSPQQV ADTTSQLASA RPLVNELAKN PSLTGLATTL STTLGQPLLT GQVKLPSMAK 
181:	LLSRSAATVD DVLAGKPAAF SWRALVDNDA ARQPARAFVT VQPVVNYGAL KAGAQTSDVI 
241:	RETARALDLE KRYGAVVRLT GEQPLADDEF SSVEDGAALN GVVTLLVVFV ILWLALRSKR 
301:	MIASVLVTLF VGLVVTAALG LAMVGSLNMI SVAFMVLFVG LGVDFSIQYG VKYREERFRD 
361:	ARIDHALIGA AHSMGMPLAL ATTAVAASFF SFIPTAYRGV SELGLIAGVG MFVALLTTLT 
421:	LLPALLRLFA PPGESKTPGF PWLAPVDDYL DRHRKPILIG TLAVVIGALP LLAFLHFDFN 
481:	PLHLKDPHSE SMSTLLALKD SPEAAVNDVT LLAPSLADAD AAAKRLDALP EVGRTTTLST 
541:	FIPADQPEKR AAIATAASTL LPALTQPPAP PATDAQRVAA LKRASDLLGY AAEDHPGPGA 
601:	AAAQHLSQSL AKLAAADSAT RDRAERAFAD TLRIALNQLA ALLQPQEITR DTLPPPLVRD 
661:	WVAPDGKALV QISPKVPKGV DPNDDTMLRH FATAVKAAEP GAIGGPISIL HSANTIISAF 
721:	LHAALWSIIS ITILLWITLR RFGDVLRTLV PLLVSGIVTL EMCVVLGMSL NFANIIALPL 
781:	MLGVGVAFKV YFVMAWRAGQ TGLLHSSLTH AVLFSAATTA TAFGSLWLSH HPGTSSMGKL 
841:	LALALTCTLI GAVVFQPVLM GKPRVKRAKN QSQGINE