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2.A.6.9.2
Protein dispatched homologue 1 (dispA).  The human ortholog (Q96F81, 1524 aas) is 83% identical.  Plays a role in congenital diaphragmatic hernia (CDH) and associated pulmonary hypoplasia (PH) in humans (Takahashi et al. 2018).

Accession Number:Q3TDN0
Protein Name:Protein dispatched homologue 1
Length:1521
Molecular Weight:170130.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q3TDN0
eggNOG: NOG318867
Entrez Gene ID: 68897   
Pfam: PF03176    PF02460   
KEGG: mmu:68897   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008158 F:hedgehog receptor activity
GO:0015197 F:peptide transporter activity
GO:0007368 P:determination of left/right symmetry
GO:0060539 P:diaphragm development
GO:0009953 P:dorsal/ventral pattern formation
GO:0009880 P:embryonic pattern specification
GO:0007225 P:patched ligand maturation
GO:0007224 P:smoothened signaling pathway

References (5)

[1] “Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.”  Ma Y.et.al.   12372301
[2] “Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.”  Kawakami T.et.al.   12421714
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.”  Caspary T.et.al.   12372258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVISGSDSV LLSNGSISTS TSNPSPLSPS DGDLPAQHLG PRETPRTKAS PNGCLQLNGT 
61:	VKSSFLPLDN QRTPQTPTQC CHPCPYHHPV SSHSNHQECH PEAGLAASPA LASCRMQPHS 
121:	EYSASLCPNH SPVYQAAHCL QPSPSFCLHH PWPDHFQHQP VRQHLTIIRP SRPFKFPRSY 
181:	AALLADWPVV VLGMCTLLIV VCALVGVLVP ELPDFSDPLL GFEPRGTTIG QRLVTWNNMM 
241:	RNTGYKATLA NYPYKYAEEQ ARSHRDDRWS DDHHERERRE VDWNFQKDSF FCDVPSDGYS 
301:	RVVFASAGGE TLWNLPAIKS MCDVDNSRIR SHPQFSDLCQ RTTAVSCCPS WTLGNYIAIL 
361:	NNRSSCQKIV ERDVSHTLKL LRTCAKHYQN GTLGPDCWDK AARRKDQLKC TNVPRKCTKY 
421:	NAVYQILHYL VDKDFMTPKT ADYAVPALKY SMLFSPTEKG ESMMNIYLDN FENWNSSDGI 
481:	TTVTGIEFGI KHSLFQDYLL MDTVYPAIAI AIVLLIMCVY TKSMFITLMT MFAIISSLIV 
541:	SYFLYRVVFN FEFFPFMNLT ALIILVGIGA DDAFVLCDVW NYTKFDKPRA ETSEAVSVTL 
601:	QHAALSMFVT SFTTAAAFYA NYVSNITAIR CFGVYAGTAI LVNYVLMVTW LPAVIVLHER 
661:	YLLNIFTCFR KPQPQAYDKS CWAVLCQKCR RVLFAVSEAS RIFFEKVLPC IVIKFRYLWL 
721:	IWFLALTVGG AYIVCVNPKM KLPSLELSEF QVFRSSHPFE RYDAEFKKLF MFERVHHGEE 
781:	LHMPITVIWG VSPEDSGDPL NPKSKGELTL DSTFNIASPA SQAWILHFCQ KLRNQTFFHQ 
841:	TEQQDFTSCF IETFKQWMEN QDCDEPALYP CCSHCSFPYK QEVFELCIKK AIMELDRSTG 
901:	YHLNNKTPGP RFDINDTIRA VVLEFQSTFL FTLAYEKMQQ FYKEVDSWIS HELSSAPEGL 
961:	SRGWFVSNLE FYDLQDSLSD GTLIAMGLSV AVAFSVMLLT TWNIIISLYA IVSIAGTIFV 
1021:	TVGSLVLLGW ELNVLESVTI SVAVGLSVDF AVHYGVAYRL APDPDREGKV IFSLSRMGSA 
1081:	IAMAALTTFV AGAMMMPSTV LAYTQLGTFM MLVMCVSWAF ATFFFQCLCR CLGPQGTCGQ 
1141:	IPFPTKLQCS PFSHTLSARP GDRGPSKTHA ASAYSVDARG QKSQLEHEFY ELQPLASHSC 
1201:	TSSEKTTYEE PHTCSEFFNG QAKNLRMPVP AAYSSELTKS PSSEPGSALL QSCLEQDTVC 
1261:	HFSLNPRCNC RDAYTHLQYG LPEIHCQQMG DSLCHKCAST AGGFVQIQSS VAPLKASHQA 
1321:	AEGLLHPAQH MLPPGMQNSR PRNFFLHSVQ HFQAQENLGR TSTHSTDERL PRTAELSPPP 
1381:	SDSRSTESFQ RACCHPENNQ RRLCKSRDPG DTEGSGGTKS KVSGLPNQTD KEEKQVEPSL 
1441:	LQTDETVNSE HLNHNESNFT FSHLPGEAGC RSCPNSPQSC RSIMRSKCGT EDCQTPNLEA 
1501:	NVPAVPTHSD LSGESLLIKT L