TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.60.1.1









Organic anion transporter, Oatp1 (SLC21A1) (substrates: digoxin, bromosulfophthalein, conjugated (taurocholate) and unconjugated (cholate) bile salts; conjugated and unconjugated steroid hormones, eicosanoids, peptides, drugs, toxins, other organic anions (e.g., bilirubin, glucuronide) and organic cations (e.g., N-methylquinidine, rocuronium)) (Na+-independent)

Eukaryota
Metazoa
Oatp1 of Rattus norvegicus
*2.A.60.1.2









Prostaglandin transporter, Pgt or PGT (SLC21A2) (substrates: eicosanoids including several prostaglandins and thromboxanes). Prostaglandins (PGs) transported include PGE2 PGF and PGH2 (Chi and Schuster, 2010).  Pgt is an important mediator of ovulation, and its inhibitors are potential candidates for nonhormonal contraception (Yerushalmi et al. 2016). PGT is involved in the clearance of PGE2 from the brain during the recovery phase of LPS-induced acute-phase responses (Hosotani et al. 2015).

Eukaryota
Metazoa
Pgt of Rattus norvegicus
*2.A.60.1.3









Organic anion transporter, Oat3a (SLC21A7) (substrates: thyroid hormones (triiodothyronine and thyroxine) cholate, taurocholate hormones and their conjugates, eicosanoids, other organic anions and cations).  Mediates uptake of ciprofloxacin in mice (Arakawa et al. 2012).

Eukaryota
Metazoa
Oat3a of Rattus norvegicus
*2.A.60.1.4









Organic anion transporter, OatK1 (SLC21A4) (substrates: bile salts, hormones and their conjugates, eicosanoids, toxins, drugs, methotrexate, zidovudine)

Eukaryota
Metazoa
OatK1 of Rattus norvegicus
*2.A.60.1.5









Organic anion transporter, OATP2, OAT1B1, SLCO1B1 or OATP1B1 (LST-1) (SLC21A6) (substrates: mono- and bis-glucuronosyl bilirubin, sulfobromophthalein, taurocholate (Km = 14 μM), estrone sulfate, dehydroepiandrosterone sulfate, estradiol-17 β-D-glucuronide and other conjugated steroids (i.e., estrone 3-sulfate), leukotriene C4, eicosanoids (i.e., prostaglandin E2, thromboxane B2, leucotriene C4 and leucotriene E4), thyroid hormones (i.e., thyroxine and triiodothyronine), other organic anions, drugs, β-lactam antibiotics, ochratoxin, xenobiotics, ouabain, valsartan and pravastatin). OatP-C/1B1(SLC21A) (Hogg et al. 2015; Qi et al. 2017). The bile acid (cholic acid) uptake transporter, OatP-C (transports cholic acid without symport with GSH) (Briz et al., 2006; Degorter et al., 2012). Amino acids in TMS2 essential for estrone-3-sulfate transport have been identified (Li et al., 2012).  OATP1B1 exhibits polymorphism related to neonatal hyperbilirubinemia (Zhang et al. 2010).  Tyr258 and Trp259 in TMS6 play different roles in substrate specificity (Huang et al. 2013).  Cyclic ABP aromatic ring substituents like the chloro-phenyl-thio groups increase their ability to inhibit OATP-mediated transport (Herfindal et al. 2014).  TMS11 influences substrate binding, stability and trafficking (Hong et al. 2015).  Transports danoprevir (hepatitis C virus protease inhibitor) (Brennan et al. 2015).  Residues have been identified that are involved in modulating transport kinetics, and this participation strongly depends on the substrate used in the assay (Gruetz et al. 2016).

Eukaryota
Metazoa
SLCO1B1 of Homo sapiens
*2.A.60.1.6









Mouse liver Oatp2 (Slco1a4, Oatp1a4) of 670 aas and 12 TMSs in a 3 + 3 + 3 + 3 + 3 arrangement. Substrates include estrone-3-sulfate, dehydroepiandrosterone sulfate, ouabain, β-lactam antibiotics, BQ-123, digoxin (Km = 5.7 μM), bromosulfophthalein but not taurocholate, rocuronium or deltorphin II. Also transports thyroid hormones. Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011). It catalyzes transport of substrate drugs with neuroprotective properties across the blook-brain barrier (BBB) (Abdullahi et al. 2017).

Eukaryota
Metazoa
Oatp2 (SLC21A5) of Mus musculus
*2.A.60.1.7









Oat9 (SLC21A9) (transports bile salts, eicosanoids and drugs)
Eukaryota
Metazoa
Oat9 of Rattus norvegicus
*2.A.60.1.8









Oat4 (SLC21A10). Transports bile salts, eicosanoids, urate, hormones and their conjugates, toxins and other anions.  Functions in urate reabsorption across the renal appical membrane (Prestin et al. 2014).

Eukaryota
Metazoa
Oat4 of Rattus norvegicus
*2.A.60.1.9









Oat12 (SLC21A12) (transports bile salts, hormones (T3) and eicosanoids (prostaglandin E2))
Eukaryota
Metazoa
SLCO4A1 of Homo sapiens
*2.A.60.1.10









Brain Oat14 (SLC21A14) (transports bidirectionally thyroxine (T4; prothyroid hormone; Km=0.2 μM), triiodothyronine (T3; Km=1.2 μM), amphipathic organic anions such as 17-β-estradiol-D-17-β-glucuronide (Km=10 μM), cerivastatin (Km=1 μM) and troglitazone (Km=0.8 μM)) (Sugiyama et al., 2003)

Eukaryota
Metazoa
Oat14 of Rattus norvegicus (NP_445893)
*2.A.60.1.11









OATP4C1 kidney (basolateral membrane of proximal tubule cells), organic anion transporter (transports cardiac glycosides [digoxin, Km=8 μM; ouabain, Km= 0.4 μM], thyroid hormones (thyroxine and triiodothyronine), cAMP, and methotrexate (Mikkaichi et al., 2004)
Eukaryota
Metazoa
SLCO4C1 of Homo sapiens
*2.A.60.1.12









OAT8/1B3(SLC21A) The bile acid (cholic acid)/glutathione (GSH:bile acid = 2.1) exporter (Briz et al., 2006). Also transports the octapeptide, cholecystokinin (CCK-8) (Gui and Hagenbuch, 2008) and danoprevir (hepatitis C virus protease inhibitor) (Brennan et al. 2015). Forms homo and hetero oligomers, but the monomer is the active species (Brennan et al. 2015). Forms homo and hetero oligomers, but the monomer is the active species (Zhang et al. 2017).

Eukaryota
Metazoa
SLCO1B3 of Homo sapiens
*2.A.60.1.13









Liver anion transporter OatP of the little skate (689aas) (Cai et al., 2002)
Eukaryota
Metazoa
OatP of Leucoraja (Raja) erinacea (Q8UVG4)
*2.A.60.1.14









The Na+-independent organic anion transporter, OATP-A (OatP1, Oat1A2, OatP1A2, SLC21A3, SLCO1A2 of 670 aas).  Transports various anions such as cholate and taurocholate as well as the quinolone antibacterial agent levofloxacin and Ochratoxin (Ota) (Maeda et al., 2007; Qi et al. 2017). Also transports thyroid hormones. The transport of primary and secondary thyroid hormone transporters has been reviewed (Kinne et al., 2011).  Transports luciferin, the substrate of luciferase (Patrick et al. 2014).

Eukaryota
Metazoa
SLCO1A2 of Homo sapiens
*2.A.60.1.15









OAT family 1C1 protein, isoform 1, Oatp1c1; transports thyroid horomone and other organic anions (Westholm et al. 2010). (83% identical to 2.A.60.1.10). Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011) and (Bernal et al. 2015). Together with MTC8 (TC# 2.A.1.13.10), OATP1C1 controls skeletal muscle regeneration (Mayerl et al. 2018).

Eukaryota
Metazoa
SLCO1C1 of Homo sapiens
*2.A.60.1.16









solute carrier organic anion transporter family, member 5A1
Eukaryota
Metazoa
SLCO5A1 of Homo sapiens
*2.A.60.1.17









solute carrier organic anion transporter family, member 6A1
Eukaryota
Metazoa
SLCO6A1 of Homo sapiens
*2.A.60.1.18









solute carrier organic anion transporter family, member 3A1
Eukaryota
Metazoa
SLCO3A1 of Homo sapiens
*2.A.60.1.19









Solute carrier organic anion transporter family member 2A1 (Prostaglandin uptake transporter, PGT) (Solute carrier family 21 member 2). Transports prostaglandin E2 and plays a role in F4 mediated neonatal diarrhoea. (Schuster 2002; Ohkura et al. 2014).

Eukaryota
Metazoa
SLCO2A1 of Homo sapiens
*2.A.60.1.20









Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B, OAT2B1 or OATP2B1) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Solute carrier family 21 member 9).  Catalyzes anion exchange in the placenta with cytoplasmic glutamate as the probable exchanging anion (Lofthouse et al. 2015) as well as uptake of ochratoxin (OTA) (Qi et al. 2017).  A trp residue in the middle of TMS11 is essential (Bian et al. 2016). TMSs 1, 2, 4 and 5 seem to form the substrate binding pocket, and TMS 1 is also essential for stability (Fang et al. 2018). The inhibitory effects of the main soy isoflavones (daidzin, daidzein, genistin, genistein, glycitin, glycitein, biochanin A, formononetin) and their metabolites formed in vivo (S-equol, O-desmethylangolensin) towards human OATP2B1 transporter have been characterized (Navrátilová et al. 2018). Aglycones of soy isoflavones and the main biologically active metabolite S-equol were able to inhibit hOATP2B1-mediated transport with Ki values for most aglycones ranging from 1 to 20 muM (Navrátilová et al. 2018).

Eukaryota
Metazoa
SLCO2B1 (OatP2B1) of Homo sapiens
*2.A.60.1.21









Oat33Ea of 745 aas with 12 TMSs in a 3 + 3 + 3 + 3 arrangement.

Eukaryota
Metazoa
Oat33Ea of Drosophila melanogaster
*2.A.60.1.22









Oat homologue of 816 aas

Eukaryota
Metazoa
Oat homologue of Aedes aegypti
*2.A.60.1.23









Oatp1p1 steroid hormone transporter of 613 aas and 11 TMSs (Popovic et al. 2013).

Eukaryota
Metazoa
Oat1p1 of Danio rerio (Zebrafish) (Brachydanio rerio)
*2.A.60.1.24









Organic anion transporter, Oatp of 733 (or 724) aas and 12 TMSs (Mulenga et al. 2008).

Eukaryota
Metazoa
Oatp of Amblyomma americanum (Lone star tick)
*2.A.60.1.25









facilitative organic anion carrier, Slco1a6 of 670 aas and 12 TMSs. Also called Kidney-specific organic anion-transporting polypeptide 5 (Oatp5).  Transports bile acids such as taurocholic acid and other anionic compounds (Tian et al. 2015).

Eukaryota
Metazoa
Oatp5 of Mus musculus
*2.A.60.1.26









OATP1C1 of 710 aas and 12 TMSs.  Transports pro-thyroid hormone T4 with high affinity (Nele Bourgeois et al. 2016).

Eukaryota
Metazoa
OATP1C1 of Gallus gallus (Chicken)
*2.A.60.1.27









Drosophila Malpighian tubule transporter, Oatp58Dc, of 789 aas and 12 TMSs (Eraly et al. 2004; Chahine et al. 2012).

Eukaryota
Metazoa
Oatp of Drosophila melanogaster (Fruit fly)
*2.A.60.1.28









Thyroid hormone transporter, OATP1C1, of 710 aas and 12 TMSs in a clear 3 + 3 + 3 + 3 arrangement (Zada et al. 2017).

Eukaryota
Metazoa
OATP1C1 of Danio rerio (Zebrafish) (Brachydanio rerio)
*2.A.60.1.29









LST-3TM12 (LST3; SLCO1B7 is a product of splicing of SLCO1B3 and SLCO1B7, and encodes a protein with 640 aas and 12 TMSs. LST-3TM12 mRNA was verified by polymerase chain reaction showing liver enriched expression (Malagnino et al. 2017). LST-3TM12 is expressed in the PM and ER of hepatocytes and is associated with enhanced cellular accumulation of dehydroepiandrosterone sulfate (Vmax 300 pmol/mg/min; Km 34 µM) and estradiol 17-beta-glucuronide (Vmax 30 µmol/ mg/min; Km 33 µM) (Malagnino et al. 2017).

Eukaryota
Metazoa
LST3 of Homo sapiens