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2.A.60.1.10
Brain Oat14 (SLC21A14) (transports bidirectionally thyroxine (T4; prothyroid hormone; Km=0.2 μM), triiodothyronine (T3; Km=1.2 μM), amphipathic organic anions such as 17-β-estradiol-D-17-β-glucuronide (Km=10 μM), cerivastatin (Km=1 μM) and troglitazone (Km=0.8 μM)) (Sugiyama et al., 2003)

Accession Number:Q9EPZ7
Protein Name:SLC21A14 aka OAT14
Length:716
Molecular Weight:78627.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Thyroxine, Triiodothyronine, 17-beta-estradiol-D-17-beta-glucuronide, Cerviastatin, Troglitazone

Cross database links:

Genevestigator: Q9EPZ7
eggNOG: maNOG15261
RefSeq: NP_445893.1   
Entrez Gene ID: 84511   
Pfam: PF07648    PF03137   
KEGG: rno:84511   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015125 F:bile acid transmembrane transporter activity
GO:0015721 P:bile acid and bile salt transport
GO:0006811 P:ion transport

References (1)

[1] “Blood-brain barrier genomics.”  Li J.Y.et.al.   11149669

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS FVYFAKALTE 
61:	GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCLVMG 
121:	FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL TPNISPCYLE SSSPSPRSIV GKSQNKINDE 
181:	CEVDTSSSMW VYVFLGNLLR GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI 
241:	FGFLLGSLCA KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK 
301:	TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL KSLFRNPVYI 
361:	LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG LINIPAVALG IFSGGIVMKK 
421:	FRLGICEATK LYLGSSVFGY LLFLSLFALG CENSSVAGLT VSYQGTKPVS YHERALFSDC 
481:	NSRCKCSDSK WEPMCGDNGI TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG 
541:	MMGRCQKDNG CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV 
601:	RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT TLLGTVSVFL 
661:	STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR DHGLQPKYWP GKETRL