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2.A.60.1.11
OATP4C1 kidney (basolateral membrane of proximal tubule cells), organic anion transporter (transports cardiac glycosides [digoxin, Km=8 μM; ouabain, Km= 0.4 μM], thyroid hormones (thyroxine and triiodothyronine), cAMP, and methotrexate (Mikkaichi et al., 2004)

Accession Number:Q6ZQN7
Protein Name:Solute carrier organic anion transporter family member 4C1
Length:724
Molecular Weight:78948.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Cardiac glycosides, Ouabain, Thyroxine, Triiodothyronine, methotrexate, cAMP

Cross database links:

NOG320775
Genevestigator: Q6ZQN7 Q6ZQN7
HEGENOM: HBG717600 HOG000231270
RefSeq: NP_851322.3   
Entrez Gene ID: 353189   
Pfam: PF07648    PF03137   
OMIM: 609013  gene
KEGG: hsa:353189    hsa:353189   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0030154 P:cell differentiation
GO:0006811 P:ion transport
GO:0007275 P:multicellular organismal development
GO:0007283 P:spermatogenesis
GO:0005886 C:plasma membrane
GO:0043252 P:sodium-independent organic anion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.”  Mikkaichi T.et.al.   14993604
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.”  Chu X.-Y.et.al.   17314201
[4] “Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.”  Mikkaichi T.et.al.   14993604
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.”  Chu X.-Y.et.al.   17314201

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSAKGIENL AFVPSSPDIL RRLSASPSQI EVSALSSDPQ RENSQPQELQ KPQEPQKSPE 
61:	PSLPSAPPNV SEEKLRSLSL SEFEEGSYGW RNFHPQCLQR CNTPGGFLLH YCLLAVTQGI 
121:	VVNGLVNISI STVEKRYEMK SSLTGLISSS YDISFCLLSL FVSFFGERGH KPRWLAFAAF 
181:	MIGLGALVFS LPQFFSGEYK LGSLFEDTCV TTRNSTSCTS STSSLSNYLY VFILGQLLLG 
241:	AGGTPLYTLG TAFLDDSVPT HKSSLYIGTG YAMSILGPAI GYVLGGQLLT IYIDVAMGES 
301:	TDVTEDDPRW LGAWWIGFLL SWIFAWSLII PFSCFPKHLP GTAEIQAGKT SQAHQSNSNA 
361:	DVKFGKSIKD FPAALKNLMK NAVFMCLVLS TSSEALITTG FATFLPKFIE NQFGLTSSFA 
421:	ATLGGAVLIP GAALGQILGG FLVSKFRMTC KNTMKFALFT SGVALTLSFV FMYAKCENEP 
481:	FAGVSESYNG TGELGNLIAP CNANCNCSRS YYYPVCGDGV QYFSPCFAGC SNPVAHRKPK 
541:	VYYNCSCIER KTEITSTAET FGFEAKAGKC ETHCAKLPIF LCIFFIVIIF TFMAGTPITV 
601:	SILRCVNHRQ RSLALGIQFM VLRLLGTIPG PIIFGFTIDS TCILWDINDC GIKGACWIYD 
661:	NIKMAHMLVA ISVTCKVITM FFNGFAIFLY KPPPSATDVS FHKENAVVTN VLAEQDLNKI 
721:	VKEG